Examination of the Immunological Role of Toll-Like Receptor 9 on Red Blood Cells.

Toll-like receptors 7 and 8 as therapeutic targets for human diseases.

Toll-like receptor 7 (TLR7) and TLR8 respond to pathogen-derived single-stranded RNA (ssRNA), orchestrating innate immune defense responses upon infections. However, aberrant recognition of endogenous ssRNAs by these sensors can cause various pathologies, including systemic lupus erythematosus (SLE), familial histiocyt...

Examining Inflammatory Effects of Reticulocyte Erythrophagocytosis in Human Macrophage Cultures.

Toll-Like Receptors 2 and 4, Nitric Oxide, and Myeloid Differentiation Primary Response 88 in Women Infected with Toxoplasma Gondii

Background: The host resistance to Toxoplasma gondii is initiated by innate recognition of Toll-like receptors (TLRs), which reach the adaptor myeloid differentiation primary response 88 (MyD88) to drive interferon-γ (IFN-y)-dependent nitric oxide (NO) production. Human studies of the integration of these mediators...

A Flow Cytometric Method of Determining CD71+ Erythroid Cells in Neonatal Whole Blood.

TLR8 Stimulation Leads to Microenvironment Activation and Enhanced Antibody-Dependent Cellular Responses in CLL

Results suggest that TLR8 agonists may help counteract the suppressed phenotypes of immune effector cells and may enhance the efficacy of antibody therapy for CLL.

Kupffer cells are key mediators of antigen-specific immune tolerance by peptide-coupled red blood cells

Induction of antigen-specific immune tolerance is the most precise method for reverting an autoreactive immune response in diseases such as multiple sclerosis (MS). Coupling red blood cells (RBCs) with a cocktail of MS immunodominant peptides is a promising approach to induce antigen-specific immune tolerance in patien...