World Journal of Clinical Pediatrics

Mapping Primary Outcome Domains in Pharmacological Trials for Children with Neurodevelopmental Disabilities: A Cross-sectional, Registry-based Landscape Analysis of ClinicalTrials.gov

Neurodevelopmental disabilities (NDDs) are among the most common chronic childhood conditions and are frequently managed pharmacologically. However, the outcome measures used in clinical trials may not adequately capture treatment effects that are meaningful to affected children and their families. This cross-sectional...

World Journal of Clinical Pediatrics

Children with Intellectual Disability and Adolescents: Burden, Settings of Care, and Emerging Approaches

This paper reviews five interconnected domains of youth mental health: depression and anxiety, school based mental health systems, suicide prevention, digital mental health interventions, and the relationship between trauma exposure and resilience and concludes with implementation priorities for resource constrained se...

Long-term neurodevelopmental and psychiatric risks after general anesthesia in early childhood: a nationwide population-based cohort study.

Genetic Etiology and Neurodevelopmental Outcomes in Children With Craniosynostosis: A 15-Year Single-Center Retrospective Study.

BACKGROUND The traditional distinction between syndromic and nonsyndromic craniosynostosis has guided clinical management, but recent genomic advances suggest these categories represent a continuous spectrum rather than discrete entities. Data on genetic etiologies and long-term neurodevelopmental outcomes in Asian pop...

Child Growth Stunting: A Comprehensive Scientific Literature Review of Epidemiology, Etiology, Pathophysiology, and Evidence-Based Interventions

Background: Child growth stunting, defined as a height-for-age z-score (HAZ) below −2 SD based on World Health Organization standards, remains a major global public health challenge, affecting approximately 149 million children under five worldwide. Progress has stalled well short of the World Health Assembly target of...