Aug 2026· Current Microbiology· Vol 83· 0 citations· 60 references
Medicine
TL;DR
This multifunctional smart wound dressing is developed by integrating a chromogenic hydrogel with electrospun poly(ε-caprolactone) (PCL) fibers functionalized with quaternary ammonium moieties anchoring ionic silver to demonstrate outstanding cellular biocompatibility and real-time colorimetric detection of metabolically active microorganisms.
Overall, this study provides a pH-responsive, nanozyme-integrated fibrous membrane with combined antibacterial and pro-regenerative functions, offering a promising strategy for the treatment of bacteria-infected wounds without relying on antibiotics.
Han Lin, Jingyan Huang, Xiaoqi Xie et al.· Colloids and Surfaces B: Bio...· 0 citations
Electrospun poly-based fibers functionalized with silver and gold nanoparticles demonstrated an excellent balance of safety, cytocompatibility, and antibacterial performance, making them promising candidates for biomedical applications that require both inflammation control and antimicrobial protection.
Antónia Kurillová, Saverio Caporalini, Bahareh Azimi et al.· Frontiers in Bioengineering...· 0 citations
With its integrated hemostatic, antioxidant, antibacterial, and pro-regenerative properties, the CBOS hydrogel offers a viable and attractive therapeutic approach for complex wound tissue repair.
Xueyan Hou, Yanan Lu, Tenglong Xu et al.· ACS Applied Materials and In...· 0 citations
Diabetic chronic wounds remain a major clinical challenge due to persistent infection, excessive inflammation, and impaired tissue regeneration. Herein, we report a multifunctional peptide-based antibacterial hydrogel (PAHG) for treating infected wounds, constructed through the incorporation of Cys-Arg-NH2 (CR)-Ag nanoassemblies into a bioactive matrix. In this design, the CR dipeptide enables in situ reduction and stable coordination of silver ions, yielding CR-Ag nanoassemblies with controlled silver release and enhanced biocompatibility. Co-assembly of this antibacterial component with chitosan, gelatin, collagen, and epidermal growth factor (EGF) affords a three-dimensional hydrogel network that provides a moist wound microenvironment, structural support, and sustained release of pro-regenerative cues. The resulting PAHG system exhibits excellent antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus, with inhibition efficiencies exceeding 80%, while maintaining high cytocompatibility with human skin fibroblasts (∼150% viability). In a diabetic infected wound model, PAHG significantly accelerates wound healing, achieving nearly complete closure within 12 days, accompanied by enhanced collagen deposition and no noticeable histopathological abnormalities in major organs. By integrating molecularly engineered antibacterial nanoassemblies with rationally designed multicomponent hydrogels, this work provides a promising strategy for the development of bio-based antimicrobial materials and chronic wound dressings.
Heng Ge, Wen Yuan, Yulin Sun et al.· Journal of materials chemist...· 0 citations
The incorporation of cobalt-doped carbon quantum dots into injectable, biocompatible hydrogels capable of both sensing pH and eliminating bacteria is reported, demonstrating the potential of ultrasmall metal-doped CǪDs for infection control and their integration into 3D matrices as multifunctional theragnostic platforms.
A. Truskewycz, S. Houshyar, Line Pedersen et al.· bioRxiv· 0 citations
It is demonstrated that the catechol-nanocellulose/chitosan polymeric hydrogel effectively overcomes adhesion, infection, and oxidative stress barriers in diabetic wound healing, making it a promising candidate for difficult-to-heal chronic ulcers.
