TL;DR
RG exerted a protective effect on HAs against OGD/R-induced impairment via the miR-30d-5p/AKT1 mechanism, and the motor coordination and learning/memory abilities of CI mice were enhanced.
BACKGROUND Vascular dementia (VD) is a major cause of cognitive decline associated with cerebrovascular dysfunction, and effective therapeutic strategies remain limited. Ligusticum wallichii is a traditional medicinal herb with neuroprotective activity. METHODS This study investigated the protective effects of L. wal...
Objective: Jujuboside A (JuA) possesses anti-inflammatory and antioxidant activities; however, its role and mechanisms of action in ischemic stroke (IS) remain unclear.Methods: A mouse MCAO was established to evaluate the effects of different doses of JuA on brain water content, neurological function scores, behavioral...
ETHNOPHARMACOLOGICAL RELEVANCE Houshiheisan (HSHS), a classical formula from the Synopsis of the Golden Chamber, is traditionally used for stroke and is known for its wind-dispelling and deficiency-tonifying properties. While HSHS has been confirmed to significantly reduce tissue necrosis following cerebral ischemia, i...
Recent studies have demonstrated that ferroptosis plays a crucial role in neuronal cell death following cerebral infarction. Our previous research showed that gastrodin (GAS) significantly improved neurological function in rats subjected to middle cerebral artery occlusion (MCAO); however, the underlying mechanisms rem...
ETHNOPHARMACOLOGICAL RELEVANCE BYHWD, a classical prescription for post-stroke rehabilitation, protects against cerebral ischemia by modulating microglial polarization, oxidative stress, and lipid metabolism. OBJECTIVE To investigate the mechanism by which Buyang Huanwu Decoction regulates arachidonic acid metabolism...
Tar improved CIRI induced inflammation and ferroptosis through regulating the AKT/NF‐κB pathway and reversed the protective effects of Tar in OGD/R‐induced PC12 cells.
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