TRIM9-Mediated Degradation of SMAD4 Promotes Pyroptosis and Disruption of the Endothelial Barrier in Aortic Dissection Disease

ACAN regulates VSMC mitochondrial homeostasis through the YAP1/TAZ pathway and contributes to the onset and progression of aortic dissection

REDD1 Silencing Aggravates Aortic Dissection and Promotes VSMC Apoptosis with Autophagy-Related Changes

Background: Aortic dissection (AD) is a life-threatening vascular disease with high mortality, yet its molecular pathogenesis remains incompletely understood. This study investigated the role of regulated in development and DNA damage responses 1 (REDD1) in vascular smooth muscle cells (VSMCs) apoptosis and the underly...

TRAF4-mediated PRMT5 ubiquitination destabilizes GPX4 and promotes endothelial ferroptosis in atherosclerosis.

The results showed that TRAF4 was upregulated in atherosclerotic tissues, the public dataset, and ox-LDL-treated HCAECs and the TRAF4-PRMT5-GPX4 axis may represent a therapeutic target in AS.

ADAMDEC-1 promotes atherosclerosis progression by interacting with ACTN4 and modulating the PTEN-PI3K/AKT signaling axis

AKT1-dependent phosphorylation of PRMT5 prevents Siah1a-mediated CtBP1/2 ubiquitination to contribute to abdominal aortic aneurysm progression.

AIMS Abdominal aortic aneurysm (AAA) is a progressive vascular disease characterized by chronic inflammation and extracellular matrix (ECM) degradation. Although C-terminal binding protein 1 and 2 (CtBP1/2)-mediated transcriptional activation has been implicated in AAA progression, the upstream mechanisms regulating Ct...

USP14-mediated deubiquitination of KRT19 promotes pyroptosis in myocardial ischemia/reperfusion injury.

BACKGROUND Myocardial ischemia/reperfusion (MI/R) injury remains a major clinical challenge characterized by inflammation and progressive cardiomyocyte loss. Although pyroptosis is known to drive this pathogenesis, the upstream molecular switches that trigger the pyroptotic cascade remain poorly understood. Here, we in...