Insomnia phenotypes and neurocognitive biomarkers.

Chronic Sleep Deprivation as a Risk Factor for Cognitive Decline and Mood Disorders: Neurobiological Mechanisms and Therapeutic Implications

This review synthesises current evidence on sleep physiology, the neurobiological basis of sleep deprivation effects, specific cognitive and mood consequences, vulnerable populations, diagnostic approaches, therapeutic strategies, and public health implications, with the goal of providing a comprehensive foundation for...

What can narcolepsy teach us about hypocretin and dementia?

Sleep and circadian disturbances are associated with cognitive decline and dementia. Narcolepsy type 1 (NT1), characterized by severe sleep-wake disruption and loss of hypocretin, would therefore be expected to predispose individuals to premature brain aging. Yet available biomarker and neuroimaging findings do not con...

THE CLINICAL SPECTRUM OF EXCESSIVE SLEEPINESS: NEUROBIOLOGICAL MECHANISMS, ASSESSMENT, AND TREATMENT- A NARRATIVE REVIEW

Hypersomnolence disorders constitute a heterogeneous group of conditions characterized by excessive daytime sleepiness (EDS), impaired alertness, and reduced quality of life. These disorders represent a significant medical and social challenge due to their impact on cognitive functioning, occupational performance, inte...

Sleep Loss and Alzheimer’s Disease: Mechanisms, Risk Factors, and Cognitive Consequences—A Narrative Review

Sleep loss is increasingly recognized as a potentially modifiable factor in cognitive aging and Alzheimer’s disease (AD). Evidence supports a bidirectional relationship in which sleep disruption may both reflect early AD-related neurodegenerative changes and contribute to disease progression. This narrative review them...

Neurobiology of sleep apnea and cognitive impairment.

SLEEP DISORDERS AND SEVERITY OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER SYMPTOMS

Introduction: Sleep disturbances are highly prevalent among children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Difficulties initiating sleep, delayed circadian timing, insufficient or irregular sleep, sleep-disordered breathing, restless legs syndrome, and medication-related sleep changes ma...