Influences of Circadian Rhythm on Memory Formation and Underlying Neuronal Regulatory Mechanisms
TL;DR
The neural circuits and molecular feedback loops of the mammalian circadian system are summarized, the regulatory effects of environmental zeitgebers on central and peripheral rhythm entrainment are analyzed, and the multi-layer mechanisms of memory impairment mediated by reduced hippocampal neurogenesis, disrupted synaptic plasticity and epigenetic dysregulation of clock genes are elaborated.
Abstract
Circadian Rhythm disruption in modern society damages the hippocampus and leads to memory loss. However, the existing interventions for the central clock have not restored hippocampal rhythms and cognition. Therefore, this paper systematically summarizes the neural circuits and molecular feedback loops of the mammalian circadian system, analyzes the regulatory effects of environmental zeitgebers on central and peripheral rhythm entrainment, and elaborates the multi-layer mechanisms of memory impairment mediated by reduced hippocampal neurogenesis, disrupted synaptic plasticity and epigenetic dysregulation of clock genes. REV-ERBα (nuclear receptor subfamily 1 group D member 1, NR1D1) is a required molecular hub that coordinates the regulation of circadian rhythms and neural function and whole-body metabolism, according to a second proposal. This paper presents an organised theoretical system for the study of circadian regulation of memory and offers a reference for screening intervention targets in rhythm-related cognitive disorders. Research will be conducted on hippocampus-specific targeting strategies to improve the therapeutic effect of circadian rhythm disorders for memory next.