The Association Between Knee Osteoarthritis Risk Factors and Quality of Life Among Patients with Knee Osteoarthritis in Ubung Village

Association Between Obesity and Severe Knee Osteoarthritis

CORRELATION BETWEEN BODY MASS INDEX AND SEVERITY OF KNEE OSTEOARTHRITIS: A CROSS-SECTIONAL STUDY

Increased Body Mass Index is significantly associated with greater severity of knee osteoarthritis, and weight reduction may play an important role in preventing progression and improving clinical outcomes in knee osteoarthritis patients.

Correlation of Pain and Physical Disability with Radiological Features of Knee Osteoarthritis

There is a need for an integrated assessment combining clinical evaluation and radiological findings to guide treatment planning for patients with knee OA, and BMI is a major risk factor for osteoarthritis.

Association Between Center of Pressure Parameters and Self-reported factors in Osteoarthritis Across Age and BMI: A cross-sectional Study in East Azerbaijan, Iran.

Knee osteoarthritis (KOA) is a common degenerative joint disease, especially in older adults, affecting postural stability and center of pressure (COP) behavior. These biomechanical parameters may vary by age, gender, and body mass index (BMI). This study aimed to explore the relationship between COP features and these individual factors, along with self-reported pain and function, in people with KOA. From a cohort of 4,355 individuals in East Azerbaijan, 333 self-reported a physician diagnosis of KOA. After excluding cases with comorbidities, 75 participants were included. Pain and function were assessed using the WOMAC and Visual Analog Scale (VAS), while COP metrics were collected using a PT-Scan® pressure platform. One-way ANOVA and Pearson correlation were used for analysis. Age demonstrated positive relationships with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscales in men (Pain LSD=341.16, p<0.001; Total LSD=2333.69, p<0.001 and Functional LSD=1391.6, p<0.001). In women, age showed positive effects on WOMAC Total (LSD=60.00; p<0.05). Body mass index (BMI) showed negative effects on WOMAC Stiffness in both genders (Men LSD=125, p<0.001; Women LSD=150, p<0.001). In examining the relationship between the characteristics of the COP and age in women, a significant relationship was seen between age and a number of characteristics of the COP, including anterior-posterior range (AP-Range-R), mediolateral range (ML-Range-L), and the area of the confidence circle (AREA_CC_L). Examining the correlation between the characteristics of pain and the COP, a significant negative correlation was found between VAS and the characteristic of the COP (fractal dimension (FD_CE_L)). in women. These results highlight the need for age- and gender-specific approaches in evaluating balance and function in KOA. .

Magnitude of weight loss and structural progression of knee osteoarthritis in adults with obesity - A prospective cohort study

Background: Obesity is the major modifiable risk factor for knee osteoarthritis (OA) but the amount of weight loss needed to reduce structural progression in the real world is not well defined. Materials and Methods: In this single-center prospective cohort study, 400 adults with obesity (body-mass index [BMI] (cid:21) 30 kg/m 2 ) and Kellgren–Lawrence grade 2–3 knee OA were enrolled and assessed at baseline and 12 months. The main outcome was structural progressors, defined as those with a loss in medial femorotibial cartilage thickness of (cid:21) 0.10 mm on 3-Tesla MRI and/or a loss in joint-space width [JSW] of (cid:21) 0.20 mm. Associations were assessed using multivariable statistical analyses. Results: Of 400 enrolled participants (mean age 58.6 years; 66.3% women), 374 (93.5%) completed follow-up; 154 (38.5%) lost <5%, 121 (30.2%) lost 5–10%, and 125 (31.2%) lost (cid:21) 10% of body weight. Of these, 93.5%, 71.1% and 21.6% progressed structurally, respectively (P<0.001). Greater weight loss was associated with significantly less cartilage and joint space loss (P<0.001). After adjustment, the odds of structural progression were markedly lower with 5–10% (adjusted odds ratio [aOR] 0.17; 95% CI 0.08–0.36) and (cid:21) 10% weight loss (aOR 0.02; 95% CI 0.01–0.04) versus <5%. Secondary outcomes also improved with greater weight loss (P<0.001). Conclusions: In adults with obesity and knee OA, greater 12-month weight loss was associated with markedly less structural progression, with a clear dose-response gradient and an apparent threshold near 10%. The clinical data presented here support weight-loss magnitude as a clinically-relevant treatment target.

The Impact of Systemic Comorbidities on the Radiographic Severity of Knee Osteoarthritis: A Cross-Sectional Analysis

A potential role for vascular and systemic mechanisms in KOA progression is supported and the importance of cardiovascular health in patients with KOA is highlighted to highlight the importance of cardiovascular health in patients with KOA.