Jul 2026· Computers in Biology and Medicine· Vol 214, pp.
111865
· 0 citations· 72 references
Medicine
TL;DR
The overall results show that the proposed hybrid fuzzy-optimization framework provides a highly accurate and robust solution for automated seizure detection with strong potential for clinical deployment.
Abstract
Epileptic seizure detection from electroencephalography (EEG) signals is a challenging task due to the nonlinear, nonstationary, and uncertain nature of neural activity. This paper proposes a novel tri-domain epileptic seizure classification framework based on an ensemble of Interval Type-2 Neuro-Fuzzy Inference Systems (IT2FIS) with fuzzy rules optimized using the Grey Wolf Optimizer (GWO). The method integrates complementary EEG features extracted from the time, frequency, and time-frequency domains to provide a comprehensive representation of seizure-related dynamics. GWO is employed to initialize and optimize the antecedent and consequent parameters of the fuzzy rules, followed by a reconstruction-aided gradient-based fine-tuning process that enhances the discriminative capability of the IT2FIS architecture. An ensemble mechanism combines the outputs of three independently trained IT2FIS classifiers to improve robustness against signal variability. The framework is evaluated using 8 fuzzy rules per domain and a GWO population of 30 wolves, under both a stratified 5-fold cross-validation protocol for tuning and an unseen hold-out test set for final assessment. Experiments on the Bonn EEG dataset demonstrate strong performance, with the three-class classification (healthy, interictal, seizure) achieving 98.68% accuracy across individual feature domains and the multi-domain ensemble reaching near-perfect classification. Specifically, the multi-domain framework achieves near-perfect (98.68-100.00%) performance across three-class and all binary clinical splits, including 100% on the challenging E-CD scenario. Across all configurations, the framework achieves macro-F1 scores above 96%. The overall results show that the proposed hybrid fuzzy-optimization framework provides a highly accurate and robust solution for automated seizure detection with strong potential for clinical deployment.
A Deep Hybrid Neural Network framework that combines Convolutional Neural Networks (CNN) with the Aquila Optimizer (AO) for the automatic detection of epileptic seizures utilizing EEG data in MATLAB is introduced.
Swati Chowdhuri, Tiyasha Mondal· International Journal of Eng...· 0 citations
This study systematically introduces and evaluates 25 less-explored time-domain features, 13 of which have no documented precedent as classification features in scalp EEG seizure detection, against 25 classical features and their 50-feature combination.
Edgar H. Ayala-Britez, Lucas Frutos, D. Pinto-Roa et al.· Machine Learning and Knowled...· 0 citations
The epileptic seizure (ES) is one of the most prominent neurological conditions, whose detection and classification from the electroencephalogram (EEG) signals is crucial for effective diagnosis of seizures, thereby eliminating the detrimental effects associated with it. However, the development of an automated ES detection system is hindered by the non-stationary, non-linear, and high-dimensional nature of the EEG signals, compounded by noise contamination and inter-subject variability. To address these challenges, this paper proposes an automated ES detection framework based on the De-mixing Multivariate Variational Mode Decomposition (D-MVMD) integrated with the Bayesian Optimized Support Vector Machine (BO-SVM). The D-MVMD decomposes multichannel EEG signals into band-limited intrinsic mode functions (BIMFs) while alleviating the correlation between corresponding modes through an ensemble correlation coefficient, while preserving the seizure characteristics from contamination. Multi-domain features capturing temporal, spectral, and non-linear dynamics of seizure activity are then extracted from the de-mixed BIMFs. ReliefF-ranked random forest-based feature selection is employed to find discriminative features, which are subsequently classified using the optimally tuned BO-SVM classifier. Experimental evaluation on the CHB-MIT demonstrates superior performance, with an accuracy of 98.52%, precision of 98.67%, sensitivity of 98.54%, specificity of 98.54%, and F1 score of 0.98. The model is also evaluated on the Siena dataset to assess its robustness across recording sessions of the same patient. Further, it is analyzed with other state-of-the-art methods, confirming its superior mode separation and enhanced seizure detection. Hence, this developed model proves itself to be an effective and robust model for detecting seizures using the multichannel EEG analysis.
T. V. Manju, M. Hota· IEEE journal of biomedical a...· 0 citations
Epilepsy is neurological disorder which is a result of abnormal brain activity which causes repetitive seizures. The analysis of electroencephalogram (EEG) is vital in determining the pattern of epileptic and facilitating clinical diagnosis. Manual interpretation of EEG signals is very cumbersome and time consuming however, because of the high-dimensional and time varying nature of the brain signals. An automated epilepsy detection (EEG) framework is trained based on deep learning. It is a signal preprocessing, time frequency transformation, hierarchical feature extraction based on a hybrid neural architecture that encodes spatial and temporal EEG features. This is followed by the classification of the learned representations with the aim of obtaining the epileptic and non-epileptic brain activity patterns. The experimental assessment shows a better performance than the traditional procedures. The currently proposed model is significantly more accurate (96.7%), sensitive (96.0%), and specific (96.2%), as compared to classical machine learning models like support vector machines (91.2% accuracy) and random forest models (92.6% accuracy). Such results suggest that the improvement in performance of these techniques will be about 4-5 percent compared to the use of conventional techniques. The framework has a high potential of aiding in stable and automatic diagnosis of epilepsy in clinical settings.
Ritu Nagila, Kalaiyarasan R., M. S. et al.· 2026 International Conferenc...· 0 citations
OBJECTIVE
This work proposes an automated system for the detection of epileptic seizures based on electroencephalogram (EEG) signals, integrating numerous metaheuristic optimization algorithms. This study aims to improve classification accuracy and computational efficiency by optimizing feature selection and classification in a machine learning-based detection system.
METHODS
The four feature extraction strategies were employed:(i) the Discrete Wavelet Transform (DWT), (ii) the DWT with the Hjorth parameters, (iii) the DWT with the statistical features, and (iv) the DWT with the statistical and Hjorth parameters. The metaheuristic- based optimization methods, Particle Swarm Optimization (PSO), Ant Colony Optimization (ACO), Bee Algorithm (BA), and Genetic Algorithm (GA) were used to select the optimal feature from each feature set. Optimized features were then classified using a Support Vector Machine (SVM) classifier.
RESULTS
DWT + PSO + SVM model showed the highest level of classification of 97.8%, which is significantly higher compared to the other combinations of feature extraction and optimization. The feature optimization using Genetic Algorithms showed better computational efficiency, whereas ACO and BA yielded performance improvement within a given feature configuration.
DISCUSSION
The better performance of the meta-heuristic-optimized models, especially the DWT-PSO hybrid, demonstrates the effectiveness and robustness of the proposed model for automated seizure detection. These findings demonstrate the appropriateness of meta-heuristic optimization for dealing with the complex feature space of EEG and enhancing detection reliability. The results are particularly meaningful to real-time seizure monitoring systems in resource-limited systems, e.g., Healthcare Internet of Medical Things (IoMT) systems.
CONCLUSION
The findings indicate the high potential of meta-heuristic optimization tools for improving the accuracy of epileptic seizure detection and the overall performance of the system. The suggested architecture provides a clear pathway for developing effective, reliable, and real- time EEG-based seizure-detection systems.
Naresh Rana, Shruti Jain· Current Medicinal Chemistry· 0 citations