2026· International Review of Cell and Molecular Biology· Vol 406, pp.
1-42
· 0 citations
Medicine
TL;DR
The molecular basis of lysosomal damage responses, including ATG8ylation, is systematically outlined, and how these networks are implicated in a broad spectrum of pathological conditions such as aging, neurodegeneration, cancer, obesity-related disorders, and immune dysfunction is explored.
Current evidence is brought together to provide a comprehensive understanding of how CMA contributes to the Hallmarks of Cancer, including sustained proliferative signaling, resistance to cell death, metabolic reprogramming, invasion and metastasis, immune evasion, and the enabling characteristics of genome instability...
Meenakshi Tiwari, Lokendra Kumar Sharma, Bandana Chakravarti et al.· Frontiers in Oncology· 0 citations
The latest research delineating the landscape and network of autophagy in developing and mature neurons is reviewed, elucidating how conserved autophagy pathways regulate neuronal homeostasis and functions at different ages.
Henry Kim, E. Wickstead, Xiaoting Zhou et al.· Nature Neuroscience· 0 citations
Autophagy, as a core mechanism for maintaining cellular homeostasis, influences differentiation and functional activation of immune cells by regulating metabolic reprogramming. Crucially, autophagy serves as a molecular switch that precisely modulates differentiation and subsequent cell fate decisions. It achieves this...
Ya-Nan Guo, Xin-Yue Zhou, Yi-Xiao Tian et al.· International Journal of Mol...· 0 citations
Lysosomes are degradative, metabolic and signaling organelles in central nervous system (CNS) cells and play essential roles in neural homeostasis, injury responses and disease progression. Changes in lysosomal function are required for neurons, microglia, astrocytes and oligodendrocyte-lineage cells to adapt to prot...
Teng-Fei Zhao, Han-Xu Huang, Yi-Fan Wang et al.· Frontiers in Chemistry· 0 citations
Dysregulation of ALP-associated processes, including autophagic flux, chaperone-mediated autophagy, endolysosomal trafficking, lysosomal pH and ion balance, and lysosomal metabolic signaling, is implicated in both the pathogenesis and progression of neurodegenerative diseases, with an emphasis on Alzheimer’s disease an...
Samantha R. McDonough, Aditya K. Rao, Jacqueline M. McAleer et al.· Molecular Neurodegeneration...· 0 citations
Membrane damage occurs in all cell types, triggered by environmental cues, pathogens or intrinsic cellular processes. To survive, cells have evolved various mechanisms to repair their membranes. Among these, the autophagic protein ATG9A, initially described as a key factor in autophagy initiation, is now known to parti...
Aurore Claude-Taupin, M. L. Corona· Ubiquitylation & Atg8yla...· 0 citations
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