This Review examines the behavioural roles, response properties and local and long-range circuitry of the rodent vHPC and considers how its computations are distributed across projection-defined neuronal subpopulations, allowing the vHPC to support flexible behaviour across affective and motivational domains.
Mental representations enable the brain to transcend the immediacy of sensory input and operate on internal models of the world. Working memory (WM) provides the neural substrate that maintains, manipulates, and accesses these representations over behaviorally relevant timescales. Early studies identified persistent ne...
Christos Constantinidis, S. Everling, Stefan Treue et al.· Biological Psychiatry· 1 citation
The superior colliculus is a conserved midbrain structure that converts sensory input into motor output to guide orienting, defensive, and appetitive behaviors. Once regarded as a reflexive sensorimotor relay, it is now recognized as a set of anatomically and functionally distinct circuits defined by cell type, laminar...
Loran Heymans, K. Reinhard, Karl Farrow· Annual Review of Vision Scie...· 0 citations
The brain must learn to associate sensory experiences with delayed physiological consequences in order to generate adaptive behavior. The insular cortex is uniquely positioned to support this function, integrating gustatory, visceral, immune, pain, affective, and metabolic information into representations of bodily sta...
Adonis Yiannakas, Haneen Kayyal, Sailendrakumar Kolatt Chandran et al.· Trends in Neurosciences· 1 citation
A timely and comprehensive view of the anterior cingulate cortex’s role in adaptive and pathological anxiety is provided and an integrative model in which ACC effects depend on subregion, projection target, and behavioral context is proposed.
Emily Dew, Alexis Jones, S. Saggu et al.· Frontiers in Psychiatry· 0 citations
Elucidating the neuronal circuitry that underpins memory formation is critical to understanding how organisms use past experience to guide adaptive behaviour. While memory formation has long been framed as the reactivation of a static ensemble of neurons established during initial learning, growing evidence suggests th...
M. Kenna, James P. Kesby, Li Xu et al.· bioRxiv· 0 citations
Abstract Background Environmental cues present during threatening situations become linked to danger. When these cues are encountered again, they trigger retrieval of a fear memory via specialized neural circuits that produce internal fear states and initiate defensive behaviors. In brain areas such as the basolateral...
A. Holmes· International Journal of Neu...· 0 citations
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