This Concise Review synthesizes the current clinical evidence supporting MSC therapy for ischemic stroke, critically examines the biological and translational determinants of therapeutic efficacy, and discusses emerging strategies, including engineered MSCs, extracellular vesicle (EV)-based therapies, and integration with neurorehabilitation.
Background Ischemic stroke is a major cause of death and disability worldwide. Current treatments, such as thrombolysis and mechanical thrombectomy, restore perfusion but do not promote tissue repair, highlighting the need for regenerative therapies. Neural stem/progenitor cells (NSPCs) have been extensively explored i...
Joel Karikari Nyarkoh, E. Asiamah, S. B. Nyarko et al.· Neurology Research Internati...· 0 citations
This Review summarizes the therapeutic landscape of stem cell interventions for TBI, encompassing mesenchymal stem cells, neural stem cells, and cell-free derivatives including extracellular vesicles (EVs) and exosomes, and examines recent advances in therapeutic engineering.
Shijun Bi, Dandan Gao, Kunyuan Zhu et al.· Frontiers in Neuroscience· 0 citations
Overall, available evidence suggests that MSCs may support neural function and repair through neurotrophic, anti-inflammatory, immunomodulatory, and regenerative mechanisms, but current clinical evidence remains limited and heterogeneous.
Mohammed S. Al-lami, Zainab Alnaji, E. Mohammed· International Journal of Hem...· 0 citations
The current body of evidence supports the safety of MSC-based interventions, but their clinical effectiveness has not yet been consistently demonstrated and future progress will depend largely on the standardization of cell preparation and treatment protocols, improved biomarker-driven patient stratification, and rigor...
M. C. Jamali, Alaa Shafie, A. J. Alqahtani et al.· Stem cell research & therape...· 0 citations
This review synthesizes the current evidence on cell-based and drug repurposing and proposes a unique phase-specific integrative framework that rationally combines these complementary strategies with reperfusion therapy and rehabilitation to achieve durable neuroprotection and meaningful recovery in ischemic stroke.
Satoshi Suda, Yuki Sakamoto, Takashi Shimoyama et al.· Journal of Nippon Medical Sc...· 0 citations
