FTO suppresses PRTN3 translation via m⁶A demethylation to block the CXCL9/CXCR3 axis and attenuate atherosclerosis.

ADAMDEC-1 promotes atherosclerosis progression by interacting with ACTN4 and modulating the PTEN-PI3K/AKT signaling axis

ZC3H13-Mediated m6A Modification of TRIM16 Suppresses EndMT and Atherosclerosis by Destabilizing Ang2 and Inhibiting the TLR4/NLRP3 Pathway.

The RNA methyltransferase zinc finger CCCH-type containing protein 13 (ZC3H13) is downregulated in atherosclerosis (AS), but its functional mechanism remains unclear. Endothelial-mesenchymal transition (EndMT) is a core pathological driver of endothelial dysfunction in AS. This study aimed to investigate the biological...

Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

The present study demonstrated that the m6A demethylase fat mass and obesity-associated (FTO) regulates autophagy, lipid metabolism and plaque vulnerability by targeting autophagy related 5 (ATG5).

FSTL1 promotes M2 polarization of macrophages via the DIP2A–Smad2/3 Axis in gastric cancer

It is indicated that FSTL1 represents a promising immunomodulatory target and highlight its potential as a therapeutic target to reprogram the immunosuppressive microenvironment and improve the efficacy of GC immunotherapy.

M6A Demethylase FTO Targets Pcsk9 to Inhibit Vascular Calcification in Chronic Kidney Disease.

BACKGROUND FTO (fat mass and obesity-associated) protein, a key N6-methyladenosine demethylase, plays a critical role in cardiovascular disease. However, its function in vascular calcification remains poorly understood. METHODS High phosphate (Pi) was used to induce calcification in vascular smooth muscle cells (VSMC...

Myeloid STING-ZBP1 Axis Drives Atherosclerosis by Inducing Macrophage PANoptosis

The STING-ZBP1 signaling cascade is established as a central regulator of macrophage PANoptosis during atherogenesis and a previously unrecognized mechanism linking innate immune signaling to inflammatory cell death in atherosclerosis is uncovered, highlighting this pathway as a promising therapeutic target for atheros...