AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
Overall, these findings suggest that LNT attenuates experimental atherosclerosis by regulating macrophage-associated HCK/GUSB expression, suppressing foam cell formation, and modulating amino acid metabolic remodeling.
Atherosclerosis (AS) is a chronic vascular pathology and a leading cause of global cardiovascular morbidity and mortality, with dysregulated lipid metabolism acting as a primary driver of its progression. 5-Methoxyflavone (5-MF), a natural flavonoid, exhibits known lipid-modulating and antioxidant properties; however,...
BACKGROUND Atherosclerotic plaque progression involves lipid accumulation, inflammation, and impaired efferocytosis, the macrophage mediated clearance of apoptotic cells. HCAR2, a metabolite sensing receptor highly expressed on macrophages, modulates immune metabolic responses, but its role in efferocytosis and atheros...
Atherosclerosis (AS) is a chronic inflammatory vascular disease driven by endothelial dysfunction, and dysregulated ubiquitination has emerged as an important pathogenic mechanism. Although deubiquitinating enzymes (DUBs) are key regulators of protein homeostasis, the role of USP40 in AS remains unknown. Here, we defin...
Findings reveal that MD‐1 promotes pro‐inflammatory (M1‐like) macrophage polarisation in atherosclerosis by inhibiting NLRP3 inflammasome activation via a cGAS‐STING dependent pathway and suggest that MD‐1 neutralisation could be a potential therapeutic strategy for atherosclerosis management.
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