TL;DR
This study provides an interfacial regulation strategy for balancing fluid management, antibacterial performance, and biosafety in advanced wound dressings with significantly improved cytocompatibility and hemocompatibility.
Timely hemostasis, bacterial inhibition, and accelerated tissue regeneration are core demands for clinical wound care. However, integrating robust wet adhesion and surface antifouling performance simultaneously remains a key bottleneck limiting conventional wound dressings. Herein, a carboxymethyl cellulose (CMC)-based...
Polysaccharide-based hydrogels with integrated bioactive functionality are highly desirable for wound dressing applications. Here, we report an injectable, self-healing hydrogel (OPC@Sal) fabricated via dynamic Schiff-base crosslinking between oxidized pullulan (OPL) and carboxymethyl chitosan (CMCS), with simultaneous...
To effectively manage bacterial infections and support tissue regeneration, developing multifunctional, biocompatible, and stable wound coverings is critical. Here, bilayer nanofiber wound dressings were developed via electrospinning, comprising a ciprofloxacin-loaded (CIP) polyvinyl alcohol (PVA) layer and a purple ca...
Large-area wounds, such as burns, extensive trauma, and chronic nonhealing ulcers, present significant clinical challenges due to excessive exudation, high infection susceptibility, and the risk of secondary injury caused by frequent dressing removal for status inspection. These challenges necessitate advanced dressi...
Bacterial infection perturbs the wound microenvironment, thereby profoundly impeding the healing process. Functional hydrogels exhibit unique advantages for treating infected wounds because they possess high drug-loading capacity and well-controlled release performance. Herein, we constructed a dynamic covalent network...
A curcumin-modified polyitaconate-based hydrogel (FPIC) that integrates antibacterial, anti-inflammatory, and antioxidant properties is developed, establishing FPIC hydrogel as a multifunctional and highly bioactive polyitaconate-based hydrogel dressing with strong promise for treating infection- and inflammation-assoc...
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