One-Pot Synthesis of Azolylmethanesulfonamido-Substituted Oxadiazoles, Thiadiazoles, and Triazoles as Antimicrobial, Antioxidant, and Anticancer Agents Supported by Molecular Docking Studies
A novel series of azolylmethanesulfonamido-substituted oxadiazoles, thiadiazoles, and triazoles synthesized via an efficient one-pot protocol facilitated by TMSNCS demonstrated a broad spectrum of biological profiles, with multiple derivatives exhibiting potent antibacterial, antifungal, antioxidant, and anticancer properties.
In vitro findings identified compounds 6a, 6m, and 6n as potent leads, exhibiting significant antimicrobial activity with minimum inhibitory concentration values ranging from 15 to 500 µg/mL and antioxidant activity with DPPH IC50 values of 6.35 ± 0.51 μM, respectively.
Preetesh Kumar Panda, S. Paidesetty, Alaka Sahoo et al.· Future Medicinal Chemistry· 0 citations
The escalating crisis of multi-drug-resistant pathogens necessitates the development of novel therapeutic scaffolds with enhanced membrane permeability and multi-target inhibitory potential. This study describes the design, synthesis, and mechanistic evaluation of five novel azo-sulfonamide hybrids (4a–e) derived from...
Samar H. Ali, M. El-Zahed, Elham Negm et al.· Asia-Pacific Journal of Scie...· 0 citations
A novel series of structurally diverse Thiazole-Linked Schiff base derivatives (LM-1 to LM-10) was synthesisedviaa three-step protocol involving nucleophilic substitution, Boc deprotection and Schiff base formation under mildconditions. Lemon juice was used as an efficient green catalyst and ethanol as the solvent, yie...
M. Lokhande, D. Wagare, M. Adhyapak et al.· RASAYAN Journal of Chemistry· 0 citations
The findings establish the oxadiazole‐linked scaffold, particularly lead compound, particularly lead compound 1a , as a promising foundation for developing safe and effective antimicrobial agents.
O. B. Omoyeni, N. Omisore· ChemistrySelect· 0 citations
A series of novel 1,2,4-triazole-azetidin-2-one hybrids were designed and synthesised as potential anti-tubercular agents against polyphosphate kinase 2 (PPK2), an enzyme involved in nucleotide regulation in Mycobacterium tuberculosis.
Triveni Singirisetty, Vijaya Bhaskar Kuruba, Azger Dusthackeer Vijayan Nynar et al.· Asian Journal of Chemistry· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
