Scholars Compass

Neuroplastic mechanisms of chronic pain: Implications and future directions

Chronic pain is now increasingly viewed as aberrant neuroplasticity rather than a protracted expression of peripheral nociception. This review integrates current knowledge through the lens of a peripheral-to-central paradigm, whereby peripheral sensory sensitization contributes to pain initiation, spinal excitation–inh...

Neuroimmune crosstalk in osteoarthritis pain: from synovial inflammation to pain sensitization

Pain in osteoarthritis (OA) is not explained adequately by cartilage loss or radiographic severity. Synovial inflammation, tissue damage, and neural plasticity interact across the joint, dorsal root ganglia, spinal cord, and brain to shape the intensity and persistence of symptoms. This mini review examines the synoviu...

Inhibiting nociceptor endocytosis reduces MIA-induced osteoarthritic pain behavior

Progress in pain mechanisms and management

Pain is a multifaceted sensory and emotional experience that profoundly affects human health and quality of life. It functions as a double-edged sword: while acute pain serves as a protective warning signal, chronic pain compromises physiological and psychological well-being. Pain is now widely regarded as the “fifth v...

NaV1.7-dependent peripheral sensitization drives chronic pain in Parkinson’s disease

It is demonstrated that dopaminergic neurodegeneration initiated within the brain is sufficient to drive persistent peripheral sensory neuron dysfunction and identify CRMP2-dependent regulation of NaV1.7 as a therapeutic target for Parkinsonian pain.

The excitatory neurotransmitter glutamate and its receptors: the culprits behind neuropathic pain?

Human understanding of the nature of pain has undergone a profound shift from mechanical reductionism to a multidimensional, integrative approach. Among the many types of chronic pain, neuropathic pain (NP) has long been a key focus of research in the fields of neurobiology and pain medicine, owing to its high prevalen...