Deferiprone Modulates Ferroptosis to Protect Macrophages and Liver during Neospora caninum Infection

HMOX1-mediated ferroptosis participates in gangrenous mastitis in dairy goats.

Gangrenous mastitis is a severe disease caused by bacterial infection. It can lead to sepsis and even death in affected goats, posing a significant threat to the development of the dairy goat industry. The pathogenesis of this disease is not fully understood. In this study, a Staphylococcus aureus isolate obtained from...

Artesunate in Ferroptosis and Cuproptosis Regulation: Context-Dependent Mechanisms, Interplay, and Therapeutic Implications

The discovery of ferroptosis and cuproptosis has significantly expanded the landscape of programmed cell death. Artesunate (ART), a semisynthetic derivative of artemisinin, exhibits pleiotropic pharmacological activities beyond its canonical antimalarial role, including anticancer and neuroprotective effects. However,...

Dietary iron overload enhances susceptibility to Yersinia enterocolitica infection

Interplay Between Sepsis and Ferroptosis: Unraveling Molecular Insights on Cellular Integrity

Sepsis is a complex, life-threatening disease characterized by multiple organ failure due to an abnormal systemic response to infection. Its multifaceted pathophysiology involves a dynamic balance linked pro-inflammatory and anti-inflammatory mediators, coagulation activation, and altered cellular functions. Although d...

Endoplasmic reticulum stress reduces caspofungin resistance in Cryptococcus neoformans

ABSTRACT Echinocandin antifungal drugs, such as caspofungin, inhibit β-1,3-glucan synthesis to impair cell wall formation. Caspofungin is effective in the clinic against Aspergillus and Candida species but ineffective against Cryptococcus neoformans, the fungus responsible for life-threatening meningoencephalitis in im...

Ferroptosis-like cell death associated with Vibrio parahaemolyticus infection in the clam Meretrix petechialis.

A Vibrio infection model, Ferrostatin-1 intervention and mTOR-GPX4-related analysis are integrated to provide a multi-level evidence framework for ferroptosis-like responses during V. parahaemolyticus infection in M. petechialis, offering new insights into pathogen-induced cell death mechanisms in marine bivalves.