Jul 2026· Beilstein Journal of Organic Chemistry· Vol 22, pp. 1114 - 1121· 0 citations· 33 references
Medicine
Abstract
Three rare cyano-substituted indole N-glycosides, SF-2140 (1) and its two previously undescribed derivatives, sugarnitriles A (2) and B (3), were isolated from a sugarcane endophytic actinomycete Amycolatopsis sp. JS-O27. The planar structures of 1–3 were established by HRESIMS data and detailed 1D/2D NMR spectroscopic analysis, and the conformations of the sugar moieties were deduced by the analysis of 3JH-H coupling constants and NOESY data, and comparison of their electronic circular dichroism (ECD) spectra. Compounds 1 and 3 exhibited moderate to weak antibacterial activity against Escherichia coli at 100 μg/mL.
Penicillium sp. S2014503 is a fungus found in the Antarctic. Herein, we report a new heterocyclic (1) and two semi-synthesized ones (2-3) derived from citrinin (4), the main product of S2014503. Absolute configurations of 1 and 4 were deduced by single crystal X-ray diffraction analyses. Compound 2 was analyzed to be a...
Hai-Bo Zhang, Imran Khan, Wen-Yu Cheng et al.· Journal of Asian natural pro...· 0 citations
Exolide A (1), a novel ent-18-norbeyerane diterpenoid possessing a hexacarbocyclic framework, 7/5/6/6/5/3 along with four known terpenoids (2-5) were isolated from the chloroform extract of the stems of Excoecaria agallocha. The structure of 1 was elucidated by comprehensive spectroscopic data analysis (IR, HRESIMS, 1H...
H. Patel, Umme Ummarah Fariha, Sravani Mekala et al.· Fitoterapia· 0 citations
Chemical investigation of Streptomyces sp. YD248 led to the isolation of utahmycin C (1), a new glycosylated member of the rare bacterial 1,3-dimethyl-2-azaanthraquinone family. Its structure was established by NMR spectroscopy and high-resolution mass spectrometry, revealing a β-D-glucuronic acid substituent attached...
F. Tajabadi, Andrew M. Piggott, Jeff Errington et al.· Frontiers in Microbiology· 0 citations
The roots of Croton krabas have traditionally been used as a water decoction for treatment of bloating and flatulence. The preliminary bioactivity screening revealed that the crude n-hexane and EtOAc extracts exhibited significant α-glucosidase inhibitory activity. Accordingly, the first phytochemical investigation of...
Sunita Uk-at, M. Nontakitticharoen, K. Kanokmedhakul et al.· ACS Omega· 0 citations
One new succinic acid derivative, succinacid A (1), and a natural product, (E)-2-butylidene-3-methylenesuccinic acid (2), together with seven known compounds (3-9), were isolated from the marine-derived fungus Aspergillus chevalieri. Their structures were established by spectroscopic analysis, and the absolute configur...
Hui Jia, Xin Lu, Chun-Hong Wang et al.· Natural Product Research· 0 citations
The structural diversity of strekingmycin‐type polyketides is enriched by reporting two new derivatives and providing the first crystallographic evidence for compound 3, and it demonstrates for the first time the insecticidal potential of the strekingmycin family against B. tabaci.
Peng-Fei Cui, Jia-Jun Chen, Zhao-Yu Zhu et al.· Chemistry and Biodiversity· 0 citations
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