TL;DR
Findings indicate that UCHL1 drives M1 macrophage polarization and exacerbates CRS inflammation by stabilizing HIF‑1α through deubiquitination, highlighting UCHL1 as a potential therapeutic target in CRS.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disorder that affects up to 12% of the general population. It is associated with significant morbidity and a considerable burden on the healthcare system. Tumor necrosis factor -induced protein 8-like 2 (TIPE2) is an immune-related protein...
Ulcerative colitis (UC) is an intestinal inflammatory disorder primarily driven by M1 macrophage activation and oxidative stress. p62/Sequestosome-1, a multifunctional autophagy adaptor protein, plays a critical role in regulating autophagy and inflammation. α-Methylene-γ-butyrolactone (αMγB), a conserved structural mo...
BACKGROUND The progression of intracranial aneurysm (IA) was closely associated with an imbalance in M1/M2 macrophage polarization. Neuropeptide Y receptor 1 (NPY1R) was involved in regulating IA development. However, NPY1R in IA-associated macrophages and its impact on macrophage polarization remain to be elucidated....
HCA is identified as the bioactive enantiomer responsible for the anti-ALI activity of HCA and PKM2-mediated immunometabolic reprogramming underlies its protective effects, establishing PKM2 as a promising therapeutic target and (+)-HCA as a potential lead compound for ALI treatment.
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