Aug 2026· Journal of Evolutionary Biochemistry and Physiology· Vol 62, pp. 1383 - 1393· 0 citations· 37 references
TL;DR
It is indicated that METTL14 exerts a neoplastic nature, enhancing cell survival and reducing gene expression of eEF2, which could inform novel therapeutic strategies targeting the epitranscriptomic machinery in hepatocellular carcinoma (HCC).
Results showed that PARP2 was highly expressed in hepatocellular carcinoma and related to its poor prognosis, and METTL3-mediated PARP2 m6A modification plays a vital tumor-promoter role in hepatocellular carcinoma progression.
Meng-Ke Li, Yan Zhao, Yuan Li· Toxicology and Applied Pharm...· 0 citations
KIAA1429 knockdown may suppress OS progression by inhibiting m6A-dependent SLC7A11 expression, thereby promoting ferroptosis and targeting the KIAA1429/SLC7A11 axis may represent a promising therapeutic strategy for OS.
Hui Zeng, Yun-Yan Zhong, Ding-Biao Zeng et al.· International Journal of Onc...· 0 citations
It is demonstrated that EZH2 promotes NSCLC progression through activation of the JAK2/STAT3 signaling pathway, identifying the EZH2-JAK2/STAT3 axis as a potential therapeutic vulnerability in this malignancy.
Clinically, these findings identify the METTL1/USP48/LCN2 pathway as a potential therapeutic target for cSCC and elucidated a novel oncogenic axis in cSCC, wherein METTL1 stabilized USP48 mRNA through m7G methylation modification, and USP48 in turn deubiquitinated and stabilized LCN2 protein.
Xiu-Qi Li, Lin Shu, Xiao-Qiang Li et al.· Applied Biochemistry and Bio...· 0 citations
ANW inhibits malignant phenotype of gastric cancer cells by inhibiting the activation of the JAK1/STAT3 signaling pathway, thereby inducing cell cycle arrest, promoting apoptosis, and suppressing EMT and MMP-mediated invasion and migration, suggesting the potential of ANW as a therapeutic agent for gastric cancer.
Xin-Yue Liu, Ke-Ni Zhang, Tong Qiao et al.· Nan fang yi ke da xue xue ba...· 0 citations
Findings identify SC as a potential structural scaffold exhibiting preliminary anti-tumor activity against breast cancer cells, at least in part, through modulating miR-21 and inhibition of the AKT/mTOR/ERK1/2 survival network.
Y. R. Shahin, N. Elguindy, D. Ghareeb et al.· Pharmaceuticals· 0 citations
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