The design and characterization of ATP-sensing DNA origami nanotubes provide a novel method for metabolite sensing, utilizing ATP sensors and catalytic units (ENPP1/CD73) and led to reliable ATP binding and conversion to adenosine (ADO), supporting purinergic signaling modulation.
A dynamic covalent/coordinated nanonetwork (DC2 NNW) that combines drug delivery, DNase-mimetic and ROS-scavenging functions through reaction-induced self-assembly and cerium coordination is reported.
Yan-Qiang Huang, Xiao Zhang, Wenlu Li et al.· Journal of Controlled Releas...· 0 citations
Hypoxic microenvironments arise when local oxygen supply fails to meet cellular demand and exert an influence on the progression of cancer, ischemic heart and brain injury, chronic inflammatory disorders, and other diseases. Conventional approaches, including oxygen delivery systems, small-molecule redox drugs, and nat...
Yu-Han Yang, Yun Sun, Xing Sun et al.· Advances in Materials· 0 citations
Introduction Recent studies have detected nanoplastics (NPs) in human tissues and biological fluids, raising concerns regarding their potential effects on cellular homeostasis. Nevertheless, their effects on mitochondrial regulation and mitoepigenetic processes remain poorly understood. This work aimed to study the pol...
P. K. Mishra, Aneha K. Rajan, Apoorva Chouksey et al.· Frontiers in Toxicology· 0 citations
A "trinity" synergistic design paradigm is proposed, which exploits pathological mitochondrial signals as dual-functional cues for both subcellular navigation and catalytic activation, thereby achieving temporal coupling of "targeting enrichment" and "responsive activation."
Yong-Xiang Wei, Zi-Yi Yuan, Yuan-Ke Zhang et al.· Small Methods· 0 citations
The high demand for acute kidney injury (AKI) therapy calls for the development of new therapeutics for renal management. Oxidative stress, coupled with excessive inflammation, is the main pathological mechanism for AKI. Specifically, complement component 5a (C5a) exacerbates the vicious cycle between oxidative stress...
Acute lung injury (ALI) features vascular endothelial damage, impaired barrier function, and excessive ROS accumulation, which depletes endogenous peroxidases and disrupts redox homeostasis. Transcriptomic comparison between control and ALI model groups verified marked dysregulation of genes linked to oxidative stress,...
Yi-Xuan Gao, Hao-Nan Wu, Jian Yang et al.· Advanced Healthcare Material...· 0 citations
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