Overall, the developed transferosomal system demonstrated improved permeation, sustained release, and biocompatibility, suggesting its potential as a promising topical delivery.
The developed nanoemulsion effectively addressed the major biopharmaceutical limitations of apigenin by improving its solubility, intracellular delivery, and antioxidant efficacy and establish A-NE as a stable and efficient nanocarrier platform with considerable potential for advanced intracellular antioxidant therapy.
G. H. Sree, Chennu Himasri, M. Hogade et al.· Adolescência e Saúde· 0 citations
Madecassoside, a major triterpenoid glycoside from Centella asiatica, has potential value for dermatological applications; however, its poor stratum corneum permeability is due to high hydrophilicity and large molecular size. This work focused on designing a microemulsion carrier to enhance the topical delivery of made...
Iain H. Chiu, Quoc Lam Vu, Pao-Chu Wu· International Journal of Pha...· 0 citations
INTRODUCTION/OBJECTIVE
Niosomes are nonionic surfactant-based vesicular systems. Paliperidone, which is an atypical antipsychotic used in the management of schizophrenia, exhibits poor aqueous solubility and limited oral bioavailability, which could limit its therapeutic effectiveness. This study aimed to develop and o...
Ayam Ayad, Khalid K. Al-kinani· Recent Advances in Drug Deli...· 0 citations
Background: Fungal infections remain a significant therapeutic challenge due to recurrence, limited treatment options, and reduced susceptibility to conventional antifungal agents. Allicin, a natural organosulfur compound, possesses promising antifungal activity but requires an appropriate delivery system for effective...
The developed transethosomal system showed favorable physicochemical properties, sustained drug release, stability, antioxidant and antimicrobial activity, and significant cytotoxicity against melanoma cells, which support its potential as a multifunctional topical platform for localized melanoma therapy and provide a...
Kirandeep Kaur, Preeti Patel, Balak Das Kurmi· Journal of Pharmaceutical In...· 0 citations
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