Design, development, and optimisation of an amorphous solid dispersion-based etoricoxib bigel for targeted topical anti-inflammatory drug delivery

QUALITY BY DESIGN APPROACH FOR THE DEVELOPMENT AND OPTIMIZATION OF CETIRIZINE HYDROCHLORIDE EMULGEL: FORMULATION, CHARACTERIZATION, AND IN VITRO EVALUATION

Emulgels combine the formulation attributes of emulsions and gels and are increasingly investigated as topical drug delivery systems because their rheological and release properties can be tuned through excipient selection. Cetirizine hydrochloride is a second-generation H1-antihistamine that is often used orally. Usin...

Development and Optimization of a Lupeol-Loaded Bilosomal Gel for Enhanced Topical Therapy of Imiquimod-Induced Psoriasis

Lupeol, a naturally occurring pentacyclic triterpenoid, exhibits potent anti-inflammatory and antioxidant activities, making it a promising candidate for psoriasis treatment. However, its poor aqueous solubility and limited skin permeation restrict its therapeutic application. This study aimed to develop and optimize a...

Formulation and Box-Behnken optimization of roflumilast loaded ultradeformable nanotransethosomal gel: physicochemical characterization, stability, dermal permeation, and antipsoriatic efficacy in an imiquimod-induced psoriasis model.

Dihydromyricetin-Loaded In Situ Film-Forming Emulsions: A Eudragit® RS 100-Based Strategy for Controlled Topical Delivery

Background/Objectives: Dihydromyricetin (DHM), a poorly water-soluble flavonoid with potent antioxidant and skin-rejuvenating properties, exhibits limited skin permeation. This study aimed to develop and characterize DHM-loaded in situ film-forming emulsions (FFE) using Eudragit® RS 100 as the film-forming polymer to e...

Design, Optimization, and Characterization of Nilotinib-loaded Supersaturable Self-nanoemulsifying Drug Delivery Systems for Improved Anticancer Efficacy

Nilotinib is a weakly basic, BCS Class II tyrosine kinase inhibitor with poor aqueous solubility, which may limit its oral bioavailability, particularly at higher gastrointestinal pH. In the present study, a supersaturable self-nanoemulsifying drug delivery system (sSNEDDS) was systematically developed using castor o...

DoE-guided Development of Hydroxypropyl-β-cyclodextrin Complex-loaded Curcuminoid Orodispersible Tablets for Geriatric Use

This study aimed to enhance the physicochemical properties of curcuminoids by preparing an inclusion complex and formulate an orodispersible tablet (ODT) suitable for elderly patients. A purified curcuminoid was complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD). A design of experiments was employed to optimize the...