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An FPGA-Accelerated Audio CNN for Alzheimer’s Disease Detection Using Hardware–Software Co-Design

Aug 2026 · Midwest Symposium on Circuits and Systems · pp. 850-854 · 0 citations · 17 references

Abstract

This paper presents the deployment of a speechbased Alzheimer’s disease classification CNN on the Xilinx Kria KV260 edge FPGA platform using hardware–software co-design. A lightweight 76,082-parameter network operating on log-Mel spectrograms is trained on a combined 160-sample dataset and quantized to INT8 using post-training quantization with the Vitis-AI toolchain. Audio preprocessing runs on the ARM Cortex-A53, while inference is offloaded to the DPUCZDX8G Deep Processing Unit. The FP32 baseline achieves 87.5% accuracy; post-training INT8 quantization yields 84.4% for both CPU and FPGA configurations, with INT8 FPGA and INT8 CPU producing identical predictions under strict preprocessing alignment. The deployed system achieves 0.876 ms inference latency and 1140+ FPS throughput, a $7.4 \times$ speedup over FP32 CPU execution at 157.7 FPS/W energy efficiency, compared to 26.2 FPS/W for CPU inference. These results confirm reliable FPGA acceleration for biomedical speech inference and highlight the critical role of preprocessing alignment and quantization consistency in edge deployment.

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