An approach for creating self-assembling, supramolecular hydrogels based on a peptide-polymer conjugate (PPC) as a three-dimensional (3D) cell culture platform is established and a method for the encapsulation and culture of human wound healing cells, fibroblasts, within the PPC hydrogels is developed.
Silk fibroin hydrogels are a promising platform for tissue engineering due to their biocompatibility and tunability, yet efficient cell recovery from gels remains a challenge. This work synthesizes reversible hydrogels by electrostatically-crosslinking carboxylated silk with linear and branched polyamine. Solvent cho...
Sanyukta A. Patil, Kelly A. Burke· Biomacromolecules· 0 citations
Hydrogels are widely used materials for biomedical applications. In particular, supramolecular hydrogels based on guanosine‐quadruplexes (GQ) have been utilized for drug delivery, biocatalysis, and biosensing. However, when applied as scaffolds for cell culture, existing GQ hydrogels suffer from important limitations...
Neha Thakur, Min-Ye Jin, P. Milkin et al.· Advanced Functional Material...· 0 citations
Hydrogels that recapitulate the biochemical and mechanical complexity of the extracellular matrix (ECM) are critical for advanced cell culture and tissue engineering. Here, we develop spider silk protein (spidroin)-based hydrogels from the recombinant miniature spidroin NT2RepCT mixed with VN-NT, a vitronectin peptide...
S. Korpela, U. Chatterjee, G. Greco et al.· Small· 0 citations
This review provides a comprehensive analysis of the fundamental mechanisms of thermoresponsive behaviour, major polymer systems and the most significant applications in tissue engineering and highlights future research directions needed to fully exploit the potential of thermoresponsive hydrogels in regenerative medic...
Hydrogels have emerged as promising materials across various fields, including biomedical, electronic, and robotic applications, due to their intrinsic softness and biocompatibility. Despite these advantages, the development of hydrogel‐based functional materials and devices remains limited by the narrow range of mat...
Hyeonjin Kim, Hyeseoung Lim, Ji Min Lee et al.· Advanced Functional Material...· 0 citations
Three-dimensional (3D) bioprinting enables the fabrication of complex tissue constructs with precise spatial organization of cells and biomaterials. Hydrogels are widely used as bioinks due to their biocompatibility, high water content, porosity, and tunable mechanical properties. However, many conventional, permanentl...
Ying-Ji Meng, Min Ye, Jie Gao et al.· Small Methods· 0 citations
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