TL;DR
Findings from large-scale genome-wide association studies of CM should be interpreted as hypothesis-generating candidates for future mechanistic and intervention studies rather than as direct clinical targets.
Psychiatric disorders frequently co-occur with a broad range of non-psychiatric conditions, suggesting shared biological mechanisms that transcend traditional diagnostic boundaries. Although recent studies have demonstrated substantial genetic overlap between psychiatric and other medical disorders, the genomic archite...
Evidence is found for additive effects of other genetic factors in contributing to some latent co-occurring neurodevelopmental and mental health conditions in autism.
A single latent reproductive timing factor effectively captures the shared genetic architecture across female reproductive milestones and their relationship with MDD risk, deepening understanding of reproductive biology in mental health and offer potential targets for early risk identification and intervention in women...
It is suggested that sleep disturbances may represent potential modifiable factors associated with mental health outcomes and highlight the importance of sleep-related interventions in psychiatric disease prevention and management.
Environmental risk factors for psychosis and psychopathology are often treated as non-genetic, although many are partly heritable or correlated with genetically influenced traits. We tested nine polygenic scores against 49 environmental-risk factors in 307,493 UK Biobank participants without recorded schizophrenia, b...
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