FIB-4 is associated with Gleason grade group upgrading after radical prostatectomy: a comparison of inflammatory and AST/ALT-based indices in active surveillance-eligible men.
Aug 2026· International Urology and Nephrology· 0 citations· 17 references
Medicine
TL;DR
Among routinely available blood-derived indices, the clinically relevant signal for Gleason upgrading after RP appeared to be concentrated in AST/ALT-based markers rather than inflammatory indices.
Simple Summary Selecting men with ISUP Grade Group (GG) 2 prostate cancer for active surveillance remains challenging. In this Flow, 10% (and up to 15% in selected cases) combined with low PSA density reliably identifies organ-confined, non-upgraded pathology. These quantitative thresholds provide objective criteria to...
L. Regis, Clara Perez, Jacques Planas et al.· Cancers· 0 citations
Although a PSA density threshold of 0.125 demonstrated only modest discriminative ability, PSA density may provide additional information as an adjunct to preoperative risk assessment among surgically treated patients.
F. Bıçaklıoğlu, Y. Akyol, M. S. Mert et al.· Urologia internationalis· 0 citations
OBJECTIVES
To evaluate whether total Gleason pattern 4 (GP4) length provides better risk stratification than current risk group criteria for determining potential active surveillance (AS) eligibility, using oncological outcomes after radical prostatectomy (RP).
PATIENTS AND METHODS
We identified patients with Grade G...
Sean A. Fletcher, Nicholas A. Pickersgill, Nate Aiken et al.· BJU International· 0 citations
Programmed death-ligand 1 (PD-L1) expression in Grade Group 1 (GG1) prostate carcinoma biopsies has not been established as a marker of pathological upgrading at radical prostatectomy (RP). This two-center retrospective case–control study included 172 men with GG1 carcinoma in the biopsy closest to RP: all 86 patients...
L. Pepe, V. Zuccalà, Ida Rizzuto et al.· International Journal of Mol...· 0 citations
Background and Objectives: Multiparametric magnetic resonance imaging (mpMRI) is widely used in prostate cancer diagnosis, but biopsy findings may still underestimate tumor aggressiveness. This study evaluated the association of Prostate Imaging Reporting and Data System (PI-RADS) assessment with clinically significant...
H. A. Krzepkowski, T. Ząbkowski, A. Wieczorek et al.· Journal of Clinical Medicine· 0 citations
Objective: Grading discordance between transrectal ultrasound (TRUS)-guided biopsy and radical prostatectomy (RP) specimens represents a clinically significant challenge in prostate cancer management. This study aimed to evaluate the concordance of Gleason score (GS) and prognostic grade group (GG) between TRUS-guided...
Özgecan Gündoğar, S. Bektaş, Selen Turkaslan et al.· European Archives of Medical...· 0 citations
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