Aug 2026· Biosensors & bioelectronics· Vol 313, pp.
119143
· 0 citations· 11 references
Medicine
Abstract
A compact, highly integrated dual-microchannel Mach-Zehnder interferometer (MZI) sensor based on an offset-core capillary-core fiber (CCF) is proposed for label-free and simultaneous detection of bovine serum albumin (BSA) concentration and temperature. Symmetrical C-shaped micropores are fabricated on both sides of the capillary air hole in the CCF via femtosecond laser micromachining, allowing the filling of thermo-sensitive materials to construct the temperature-sensing channel. Meanwhile, a C-shaped microcavity is inscribed at the offset fiber core to form the label-free BSA concentration-sensing channel. This design spatially isolates the temperature-sensing channel from the bio-sample microchannel, achieving two independent sensing paths. Experimental results show that the sensor delivers a temperature sensitivity of 8.884 nm/°C and a temperature resolution of 0.011 °C, and accurately monitors local temperature fluctuations during BSA detection within the concentration range of 20-60 mg/mL. This integrated fiber sensor exhibits promising application potential in disease diagnosis, therapeutic efficacy monitoring, and precision medicine, with great significance for clinical translation and biomedical basic research.
In-line fiber Mach–Zehnder interferometers (MZIs) have been widely investigated for refractive index (RI) sensing; however, variations in temperature affect the accuracy of RI measurement due to the thermo-optic effect. In this study, a cascaded core-offset in-line fiber MZI was simulated and experimentally demonstrate...
A cascaded single–mode–multimode–hollow-core fiber (SMF-MMF-HCF) optical sensor based on Fabry-Pérot interferometer (FPI) is proposed for ultra-sensitive copper ions (Cu(II)) detection. The cascaded structure provides an unfilled-air reference cavity and an air-material hybrid sensing cavity with slightly detuned free...
Jian-Bo Bao, Qiang Chen, Li-Ying Xu et al.· Journal of Lightwave Technol...· 0 citations
A highly sensitive cascaded Fabry–Perot optical fiber sensor for simultaneous measurement of temperature and high pressure is proposed. The sensor comprises a UV glue filled hollow core fiber (HCF) cascaded with an air cavity sealed in a silica capillary tube. The temperature and pressure can be measured simultaneously...
Chuan-Xin Teng, Li-Ying Shi, Yi-Hai Chen et al.· IEEE Transactions on Instrum...· 0 citations
This study proposes a dual-parameter sensor for liquid level and temperature based on etched four-core fiber (FCF) structure. The sensor employs a square four-core fiber, and its interference mechanism superimposes both multimode interference (MMI) and Mach-Zehnder interference (MZI). Owing to the absence of a central...
A fast carbon dioxide (CO2) sensor utilizing an anti-resonant hollow-core fiber with microchannel arrays is demonstrated, where the microchannel arrays along the fiber cladding are precisely fabricated by a femtosecond laser to enhance the internal gas mass transfer rate to speed up the response. We utilized the method...
Min Yang, Xue Tang, Qian Luo et al.· IEEE Photonics Technology Le...· 0 citations
Hyperbolic mode resonance (HMR) has emerged as a solution to conventional sensing limitations. HMR is introduced into a photonic crystal fiber (PCF) for sensing in this research. A dual-channel PCF sensor for both refractive index (RI) and temperature measurement is proposed. The device has two independent sensing chan...
Qi-Rui Shu, Miao-Miao Yan, Ying He et al.· Photonics· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
