Investigating the impact of chronic genotoxic and metabolic stress on senescence-associated phenotypes in the human microglia cell line HMC3 demonstrated that chronic genotoxic and metabolic stress drive distinct yet overlapping senescence programs characterised by morphological changes, mitochondrial remodelling and persistent inflammatory activation.
Cellular senescence has emerged as a key contributor to age-related skeletal deterioration; however, the defining characteristics of senescent osteoblasts remain incompletely understood, hindering efforts to identify the cellular mechanisms that drive age-associated bone loss and potential therapeutic targets. Here, we...
Tanja Frey, Hannah Vogg, Mubashir Ahmad et al.· bioRxiv· 0 citations
Current understanding of mitochondrial regulation across senescence subtypes is synthesized and how mitochondrial dysfunction actively drives senescence heterogeneity is highlighted to provide a conceptual framework for developing precision interventions in aging and cancer.
Minseo Ahn, Sung-Jin Yoon, Jae Ho Seo· Frontiers in Cell and Develo...· 0 citations
These findings identify age-associated loss of GPR81 as a driver of vascular metabolic dysfunction and cellular senescence and establish pharmacological GPR81 activation as a promising therapeutic strategy for preserving vascular homeostasis and mitigating age-associated cardiovascular disease.
Yu-Lun Wu, Hamsa Vardini Senthil Kumar, Sai Harsha Bhamidipati et al.· bioRxiv· 0 citations
This study critically examines how viral and bacterial agents induce cellular senescence, particularly in vitro, reviewing the regulatory mechanisms involved and discusses genetic variants affecting infection susceptibility and categorizes senescence markers.
E. V. Simoroz, Y. V. Antonov, G. Muravyov et al.· Vavilovskii zhurnal genetiki...· 0 citations
D dysfunction in bidirectional communication pathways between the immune system and the central nervous system, driven by immunosenescence in neural cells, including glial cells and neurons, which are postmitotic cells that can acquire phenotypic traits associated with senescence, facilitates SASP activation, leading t...
Aging is associated with impaired lung repair and increased susceptibility to injury, yet the mechanisms underlying age-associated dysfunction of alveolar type II (AT2) cells remain poorly understood. Although cellular senescence is a hallmark of aging, emerging evidence suggests that aging is also characterized by pro...
Xin-Yi Li, Zhi-Fang Fu, Dan Sun et al.· Mechanisms of Ageing and Dev...· 0 citations
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