Sep 2026· Zeitschrift für Induktive Abstammungs- und Vererbungslehre· Vol 301· 0 citations· 42 references
Medicine
TL;DR
Preclinical findings indicate that Ace2 deficiency is associated with concurrent pathological abnormalities in the brain and transient bone metabolic disturbance under short-term MPTP treatment in growing young male mice, consistent with a potential bone-brain axis pathological phenotype.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment. Oxidative stress plays an important role in disease progression in AD. However, the molecular mechanisms underlying oxidative stress in AD remain unclear and reliable biomarkers for its detecti...
Wen-Bo Dou, Xue Chen, H. Hong et al.· Biomolecules· 0 citations
Diabetes mellitus (DM) and its complications remain major clinical challenges despite advances in prevention and treatment. Histone Deacetylase 11 (HDAC11) has been implicated in glucose metabolism, insulin sensitivity, and inflammatory cytokine (IC) regulation, suggesting potential relevance to diabetes-related phen...
Yi Liang, Guang-Wen Zhu, Xin-Rui Wu et al.· Scientific Reports· 0 citations
Background Parkinson’s disease (PD) is a complex neurodegenerative disorder characterized by multifaceted molecular dysregulation. Integrating genetic approaches with metabolomics may help to systematically investigate potential links between metabolites, inflammatory proteins, and PD risk. Methods In this pilot discov...
Current mechanistic insights inspire targeted therapeutic strategies comprising α-synuclein inhibitors, mitochondrial protectants, anti-inflammatory agents, and novel cell death pathway blockers, alongside gut-brain axis interventions for PD, but these approaches face substantial challenges.
Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose pathogenesis involves complex interactions between metabolic dysfunction and neuroinflammation. The role of cuproptosis, a newly defined copper-dependent cell death pathway that is triggered during mitochondrial aerobic respiration, in PD remain...
Jing Wang, Ya-Hui Hu, Bo Wang et al.· Frontiers in Immunology· 0 citations
INTRODUCTION/OBJECTIVE
Alzheimer's Disease (AD) progresses via interconnected Aβ aggregation, tau hyperphosphorylation, neuroinflammation, and lysosomal failure, while current single-target drugs only relieve cognitive symptoms without halting pathogenesis. Gut microbiota-derived N1-methylnicotinamide (MNAM) is associa...
Xiang-Jie Qiu, Qi-Lei Zhang, Yu-Ting Meng et al.· Current Neuropharmacology· 0 citations
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