Sep 2026· Cellular and Molecular Gastroenterology and Hepatology· pp.
101910
· 0 citations
Medicine
TL;DR
It is demonstrated that thermoneutral housing markedly accelerates Western diet-induced metabolic dysfunction-associated steatohepatitis (MASH), resulting in enhanced hepatic inflammation, fibrosis, and disease severity, and it is established that providing homeostatic conditions via thermoneutral housing is an important element and a practical strategy for improving the translational relevance of preclinical MASH models.
Abstract
In this issue, Leke et al. demonstrate that thermoneutral housing markedly accelerates Western diet-induced metabolic dysfunction-associated steatohepatitis (MASH), resulting in enhanced hepatic inflammation, fibrosis, and disease severity. Importantly, thermoneutral conditions produce a hepatic transcriptional landscape that more closely resembles human MASH than conventional housing. These findings further establish that providing homeostatic conditions via thermoneutral housing is an important element and a practical strategy for improving the translational relevance of preclinical MASH models.
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