Aug 2026· Colloids and Surfaces B: Biointerfaces· Vol 268 Pt 2, pp.
116097
· 0 citations· 92 references
Medicine
TL;DR
The aim is to provide a systematic engineering design framework for next-generation biomimetic organoid culture matrices and promote their advancement toward standardization and clinical translation.
Abstract
Organoids are high-fidelity in vitro models with substantial potential in biomedicine. However, traditional animal-derived matrix gels contain undefined components and have unpredictable mechanical properties, which greatly hinder the standardization and functional maturation of organoids. In recent years, nanofibers have emerged as an ideal substrate for organoid cultivation because of their structural similarity to natural extracellular matrices and their easily tunable properties. Accordingly, this article systematically reviews the synergistic effects of nanofibers across chemical, physical, and biological dimensions, along with research progress in transitioning organoids from passive culture to active engineering. Furthermore, the review summarizes current challenges and identifies future directions for development. The aim is to provide a systematic engineering design framework for next-generation biomimetic organoid culture matrices and promote their advancement toward standardization and clinical translation.
This review systematically examines how the defining properties of bioactive ceramics intersect with the requirements of organoid formation, maturation, and transplantation and proposes that the deliberate co-design of bioactive ceramics and organoid biology represents a paradigm shift in regenerative medicine.
Shi-Han Sun, Si-Xuan Chen, Wen-Ping Ma et al.· Organoids· 0 citations
Hydrogel-based nano- and microfibers integrate the biomimetic functionality of hydrogels with the topological architecture of fibers, enabling a realistic emulation of the native extracellular matrix for various biomedical applications. Recent advances in nanofiber fabrication and stem cell engineering have positioned...
Alexander Tipan-Quishpe, Chang-Myung Oh, Myung-Han Yoon· Chemical Science· 0 citations
This Mini-Review summarizes recent advances in natural, synthetic, and hybrid biomaterials, highlighting engineered ECM–derived hydrogels, modified natural polymers, and synthetic systems with tunable viscoelasticity, degradability, and bioactive components.
Laura Klasen, Ramin Nasehi, Lennart Selzener et al.· Frontiers in Bioengineering...· 0 citations
Decellularized extracellular matrix (dECM) is a biomaterial generated by the selective removal of cellular components from native tissues while preserving the three-dimensional ultrastructure and endogenous biochemical cues of the extracellular matrix. Owing to its favorable biocompatibility, low immunogenicity, and ca...
The locomotor system organoids, which recapitulate bones, cartilage, tendons, muscles, and associated neurovascular-like structures, possess complex architecture and biomechanical properties. Traditional two-dimensional (2D) cell models struggle to effectively mimic their physiological functions. Organoid technology,...
Rui Wang, Ye Tian, Geng-Hao Wang et al.· Regenerative Biomaterials· 0 citations
This review systematically explores the synergistic potential of integrating electrospun nanofibers with three dimensional printed frameworks to create hierarchical hybrid scaffolds in regenerating tissues such as bone, cartilage, and skin.
M. Bozdağ, Muhammet Sefa Izgordu, Mehmet Niyazi Durukan et al.· Konya Journal of Engineering...· 0 citations
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