Effervescent-Assisted Solid Dispersion of Itraconazole Using Soluplus: Preparation, Molecular Docking, and Simulation Studies for Enhanced Solubility, in Vitro Dissolution, and Oral Bioavailability
Aug 2026· Journal of Pharmaceutical Innovation· Vol 22· 0 citations· 70 references
TL;DR
EASD could serve as a desirable carrier to provoke the biopharmaceutical and pharmacokinetic properties of ITZ and suggested that EASD could serve as a desirable carrier to provoke the biopharmaceutical and pharmacokinetic properties of ITZ.
INTRODUCTION/OBJECTIVE
Ebastine, a second-generation H1 antihistamine, exhibits poor aqueous solubility and consequently low oral bioavailability, limiting its clinical therapeutic efficacy. Novasome is an advanced vesicular nanocarrier system that offers a promising approach to enhance the solubility and dissolution b...
Salam ShantaTaher, Hussein J. Alhazza, H. Alkufi et al.· Recent Advances in Drug Deli...· 0 citations
Background: Voriconazole (VRZ) is a triazole antifungal agent with limited aqueous solubility, making dissolution an important formulation consideration. Solid dispersion (SD) technology can improve wetting, dispersion and the apparent dissolution of poorly water-soluble drugs. The present study investigated carboxymet...
Suraj Uddhavrao Kamble and Dr. Sanjay K. Bais· International Journal of Adv...· 0 citations
Background: Ketoconazole (KTZ) is a poorly water-soluble antifungal drug for which dissolution enhancement may improve oral formulation performance. Natural polysaccharides are attractive carriers because of their availability and biocompatibility, while chemical functionalization can modify their physicochemical behav...
Suraj Uddhavrao Kamble and Dr. Sanjay K. Bais· International Journal of Adv...· 0 citations
Ibuprofen is tough to dissolve in water and possess a limited bioavailability. To enhance dissolution, and stability, the study explores co-solvency-based solid dispersion method involving the application of tamarind seed mucilage as a natural polymer carrier. Drug:mucilage ratios of 1:0.5, 1:1, and 1:1.5, employing et...
R. Naik, Taniya Sahu, Tarun Pal et al.· Journal of Pharmaceutical Re...· 0 citations
Clarithromycin (CAL), a poorly water-soluble agent, is a novel broad-spectrum macrolide antibiotic utilised in various infections. The current study aimed to enhance its solubility and dissolution rate by formulating solid dispersions with different polyethylene glycols (PEG). These solid dispersions were synthesised v...
Halah Shukri Ali Obad, Eman Abdo Ali· Electronic Journal of Univer...· 0 citations
Mefenamic acid is a Non Steroidal anti- inflammatory drug belonging to the BCS class II. It has a low oral bioavailability due to poor aqueous solubility and poor dissolution rate. The present study was undertaken to improve the dissolution, absorption, and bioavailability of Mefenamic acid by employing spherical agg...
P. Rambabu, P. Shailaja· Adolescência e Saúde· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.