Metabolic–endocrine and epigenetic mechanisms linking obesity to male infertility: a narrative review

Immune-nutritional interactions in endometriosis: current evidence and future perspectives in disease management

Endometriosis is a chronic estrogen-dependent inflammatory disorder affecting approximately 10% of women of reproductive age. It remains a major contributor to chronic pelvic pain, infertility, and reduced quality of life. Despite considerable advances in elucidating its genetic, hormonal, and immunological basis, curr...

Immunometabolic Dysregulation in Female Obesity: Mechanistic Links to Ovarian Dysfunction, Implantation Failure, and Preeclampsia

Obesity is one of the most pressing public health challenges of our time, with a growing impact on metabolic and reproductive dysfunction in women. The expansion of visceral adipose tissue drives a chronic, low-grade systemic inflammatory state that has been associated with functional changes in the ovary, the endometr...

Neuregulin-4 and Emerging Metabolic and Reproductive Biomarkers in Polycystic Ovary Syndrome: A Narrative Review.

ABSTRACT Polycystic ovary syndrome (PCOS) is a common and heterogeneous endocrine-metabolic disorder characterized by reproductive dysfunction and increased cardiometabolic risk. Conventional diagnostic criteria do not fully capture disease heterogeneity or long-term metabolic vulnerability. In recent years, multiple e...

Polyendocrine Metabolic Ovarian Syndrome: A Brief Review.

Effective PMOS management requires an individualized, multimodal approach that integrates lifestyle medicine with targeted supplementation and pharmacotherapy to address the complex metabolic and reproductive features of the syndrome.

INSULIN RESISTANCE IN POLYCYSTIC OVARY SYNDROME: CLINICAL IMPLICATIONS AND IMPACT ON QUALITY OF LIFE — A NARRATIVE REVIEW

Polycystic ovary syndrome (PCOS) is a multifaceted endocrine and metabolic condition affecting women of reproductive age. While historically conceptualized as a reproductive disorder, current evidence indicates that PCOS extends beyond ovulatory dysfunction and hyperandrogenism to include significant metabolic, psychol...

Genetic and Epigenetic Basis of Polycystic Ovary Syndrome:A Systematic Review.