TL;DR
Current evidence of senescence as a driver of kidney disease and its potential as a therapeutic target is examined.
Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease (ESKD), and while current standard treatment strategies can slow disease progression, they are still unable to reverse progressive structural damage to the kidneys. Emerging evidence indicates that the senescence of renal tubular epithelial ce...
The ability to comprehend and therapeutically modulate graft senescence may offer novel means to maintain graft function and enhance long-term transplant survival.
Renal fibrosis is a final common pathway in chronic kidney disease (CKD), yet available therapies rarely reverse established scarring. T lymphocytes are now recognized as dynamic regulators of this process rather than simple inflammatory bystanders. This Review integrates evidence from experimental kidney injury models...
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease where chronological aging predicts the conversion to progressive MS (PMS), a phase defined by compartmentalized inflammation and accelerated neurodegeneration. While current disease modifying therapies (DMTs) are effective for managing the inflamma...
As a core organ responsible for metabolism and homeostatic regulation, the kidney performs physiological functions that encompass material excretion, fluid balance, electrolyte regulation, and endocrine control; and serves as a critical hub for maintaining the coordinated functioning of multiple organ systems. Kidney i...
Abstract Bladder dysfunction is a prevalent age-related condition that severely impairs quality of life in older adults and commonly manifests as lower urinary tract symptoms (LUTS), including frequency, urgency, incontinence, and nocturia. Cellular senescence, characterized by irreversible cell-cycle arrest accompanie...
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