TL;DR
Nummularogenin was found to be a promising multi-target anti-inflammatory lead from Z. nummularia by combined docking, validation, ADME, and MD simulation, indicating their potential as anti-inflammatory drugs for rheumatoid arthritis.
Chronic inflammatory conditions remain a major global therapeutic challenge, often limited by the adverse gastrointestinal and cardiovascular safety profiles of conventional non-steroidal anti-inflammatory drugs (NSAIDs). While plants from the genus Cassia have been used in traditional medicine for their anti-inflammat...
The combination of virtual screening, ADME studies, and MD simulations enabled the identification of phytochemicals with promising interactions toward InhA, an established anti-TB target, and should be interpreted as preliminary evidence of target engagement rather than confirmed inhibitory activity or therapeutic effi...
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that causes joint pain and inflammation. Despite the availability of various treatments, their side effects often limit their long-term effectiveness, leading to increased interest in natural compounds with fewer adverse effects. Nigella sativa (black cumin), k...
Dysregulated serotonergic signaling, including altered 5-HT₃ receptor activity, contributes to the pathophysiology of diarrhea-predominant irritable bowel syndrome (IBS-D), yet the most clinically established 5-HT₃A antagonist, alosetron, carries serious safety concerns including ischemic colitis and severe constipatio...
INTRODUCTION Sida cordifolia (SC) is traditionally used for treat inflammatory disorders; however, its molecular composition and the mechanistic basis of action remain poorly characterized. This study aimed to identify its bioactive constituents and elucidate their multi-target anti-inflammatory potential using an inte...
Chronic inflammation contributes to the pathogenesis of many degenerative diseases. Long-term use of conventional anti-inflammatory drugs may be associated with serious adverse effects, prompting the search for new natural candidates. Begonia medicinalis is a plant endemic to Central Sulawesi that is traditionally used...
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