A Review of Senescence‐Associated Secretory Phenotype‐Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy

Editorial: Cancer cell metabolism and tumor microenvironment remodel

Graphical Abstract Illustration showing interactions of cancer cells, stromal cells, immune cells, and microbiota in the tumor microenvironment, highlighting specific bioactive metabolites from each cell type and their effects on tumor survival, metabolic support, immune dysfunction, and therapy resistance.

Characterization of the Senescence-Associated Secretory Phenotype in Primary and Induced Pluripotent Stem Cell-Derived Skin Cells via Multiplex Assays.

Interconnected roles of cellular senescence and the immune microenvironment in tumor progression: from pan-cancer mechanisms to glioblastoma implications

This review systematically examines the molecular mechanisms of cellular senescence, with emphasis on the intrinsic logic governing bidirectional remodeling between senescent cells and the immune microenvironment, to provide a new theoretical foundation for next-generation precision cancer immunotherapy.

The Role of Cellular Senescence in Chronic Lung Diseases: Emerging Mechanisms and Translational Perspectives: A Narrative Review

Cellular senescence is one of the major risk factors for the onset and progression of chronic pulmonary diseases. Cellular senescence can be induced by diverse stressors, including genotoxic damage, oncogenic signaling, and therapeutic interventions. These senescent cells communicate via the release of multiple inflamm...

Integrated Transcriptomic Analysis and Machine Learning Identify THY1 as a Key Regulator of Cancer‐Associated Fibroblast Infiltration, Promoting Malignant Progression and Immune Escape in Gastric Cancer

Heterogeneity in cancer‐associated fibroblast (CAF) infiltration within the tumor microenvironment is closely associated with gastric cancer progression and immune evasion; however, precise CAF‐related diagnostic markers and actionable therapeutic targets remain scarce.

Metastatic immune microenvironment remodeling by malignant epithelial cells drives colorectal cancer hepatic metastasis: Multi-omics insights

Highlights • First identified Scissor⁺ malignant cells driving CRC HM.• Constructed a Scissor-related prognostic signature for CRC patients with HM.• Elucidated mechanisms of Scissor⁺ malignant cells worsen the microenvironment of HM.• Firet confirmed Scissor⁺ malignant cells polarize macrophages into SELENOP⁺ TAMs.