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Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer

Jiarui Mi Wenzhe Guo Li Li Si-Jing Wang Bei Wang Yan-Ping Fu Ning Hu Hai-Peng He Bo Li Wen-Yan Wang Kuo Wang

Aug 2026 · Translational Oncology · Vol 72, pp. 102935 · 0 citations · 33 references

Medicine

TL;DR

An eight‑gene prognostic model predicts survival and immunotherapy response in cervical cancer and identifies three core gene modules linked to immune evasion and malignant proliferation identified.

Abstract

Highlights • HPV infection primarily targets epithelial cells, escalating with disease progression.• HPV enhances malignant cell communication, fostering an immunosuppressive microenvironment.• Three core gene modules linked to immune evasion and malignant proliferation identified.• An eight‑gene prognostic model predicts survival and immunotherapy response in cervical cancer.

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