TL;DR
Findings establish LIPA as a critical link between lipid metabolism, ferroptosis, and immune modulation in LUAD, and provide a prognostic signature for risk stratification as well as a candidate compound for targeting lipid metabolic vulnerabilities.
: Objectives: Neuroblastoma (NB) is a heterogeneous pediatric malignancy driven by both intrinsic oncogenic programs and the stromal microenvironment. However, the critical stromal regulators associated with poor prognosis and metastasis in NB remain poorly characterized. This study aimed to identify key cancer-associa...
This study aimed to identify novel prognostic biomarkers for lung adenocarcinoma (LUAD) and elucidate their roles in tumor progression through the application of a multi-omics approach. Differentially expressed genes related to LUAD were identified using genome-wide and transcriptomics data, along with single-cell RNA...
PURPOSE The clinical management of gastric cancer is challenged by profound tumor heterogeneity and the emergence of drug-resistant cell populations. Ferroptosis, a regulated form of iron-dependent cell death driven by lipid peroxidation, has exhibited limited clinical efficacy as a monotherapy. Emerging evidence shows...
RNA sequencing of DRM-treated versus control rat C6 glioma cells identified 3747 differentially expressed genes, including 1660 upregulated and 2087 downregulated genes, with thrombospondin-1 markedly downregulated after DRM treatment, which may contribute to the anti-invasive effects of DRM.
Findings indicate that Olfactomedin-like 2B is required for HCC progression and represents a prognostic biomarker and potential therapeutic target.
The oncogenic ELFN1-AS1/LYPLA1 regulatory cascade is characterized as a potential biomarker and therapeutic target for precision management of osteosarcoma and establishes an LMRL-based for osteosarcoma prognostic stratification that reflects immune, genomic and therapeutic heterogeneity.
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