Jul 2026· Innovative Medicines & Omics· pp. 026250043· 0 citations
TL;DR
It is suggested that chrysin confers significant nephroprotective effects against PFOA-induced renal injury by mitigating oxidative stress, inflammation, and ion transport disruption, supporting its therapeutic potential as a promising nephroprotective agent for protecting against environmentally induced kidney injury.
Abstract
Pentadecafluorooctanoic acid (PFOA) is a highly persistent environmental contaminant known for its bioaccumulative nature and ability to cause adverse renal effects. Prolonged exposure to PFOA has been associated with oxidative stress, inflammation, and membrane dysfunction, which collectively contribute to renal impairment. This study investigates the nephroprotective effects of chrysin, a naturally occurring flavonoid with potent antioxidant and anti-inflammatory properties, against PFOA-induced kidney toxicity in male Wistar rats. Twenty-five rats were divided into five groups (n = 5 per group): (i) control (20% dimethyl sulfoxide), (ii) PFOA-only (5 mg/kg), (iii) 25 mg/kg chrysin + 5 mg/kg PFOA, (iv) 50 mg/kg chrysin + 5 mg/kg PFOA, and (v) 50 mg/kg chrysin-only. All treatments were administered orally for 14 consecutive days. Exposure to PFOA resulted in a significant (p < 0.05) elevation in serum creatinine, lactate dehydrogenase, and electrolyte imbalances, accompanied by reduced antioxidant enzyme activities, elevated oxidative stress markers, increased inflammatory cytokines, and disrupted ATPase activity. Chrysin pre-treatment at both 25 and 50 mg/kg markedly attenuated these toxic effects in a dose-dependent manner. It restored antioxidant defenses, normalized biochemical indices, improved electrolyte balance, and suppressed inflammation, thereby preserving renal function. These findings suggest that chrysin confers significant nephroprotective effects against PFOA-induced renal injury by mitigating oxidative stress, inflammation, and ion transport disruption, supporting its therapeutic potential as a promising nephroprotective agent for protecting against environmentally induced kidney injury.
Overall, chrysin demonstrates potent protective potential against PFOA-induced liver injury and may serve as a promising therapeutic candidate for environmental toxin-associated hepatotoxicity.
A. B. Awolesi, Moses C. Antiya, S. A. Praise· Innovative Medicines & O...· 0 citations
Emerging concerns exist with occupational/environmental exposure to 4-vinylcyclohexene diepoxide (VCD), an industrial by-product of daily-use plastic manufacturing process. This is because its biotransformation yields toxic metabolites injurious to essential body organs. This study aims to evaluate the protective potential of protocatechuic acid (PCA) against VCD-induced splenic injury. 35 adults male Wistar rats, randomly divided into 5 groups, were administered the following for 7 days: 2 mL corn oil (Group I), 100 mg/kg of VCD (Group II), 100 mg/kg of PCA (Group III), VCD + 50 mg/kg of PCA (Group IV), VCD + 100 mg/kg of PCA (Group V). Our results showed significantly elevated (p < 0.05) MDA, RONS, MPO, NO, TNF-α, and IL-1β levels and reduced GSH levels, SOD, CAT, and GST activities, as well as compromised structural integrity in spleen of rats exposed to VCD alone, indicative of its trigger of oxidative stress and inflammation. However, levels and activities of these biomarkers of oxidative stress and inflammatory mediators were significantly reversed (p < 0.05) in the spleen of VCD-exposed rats co-administered with graded doses of PCA. Our data also showed that PCA attenuated the VCD-induced distortion of the morphological pattern in the splenic tissues of exposed rats. Hence, PCA shows promise as a potential therapeutic or prophylactic agent for mitigating VCD-induced splenic injury associated with occupational/environmental exposure.
I. Maduako, S. Osawe, O. Ikponmwosa-Eweka· Journal of Phytomedicine and...· 0 citations
ELMP and EMPG demonstrate potent hepatoprotective and nephroprotective effects through multi-target antioxidant mechanisms, supporting their therapeutic potential as integrated strategies for peripheral organ protection in aluminium-induced toxicity.
C. Afuberoh, I. Ifedi, O. O. Fidelis et al.· Magna Scientia Advanced Rese...· 1 citation
Under the present experimental conditions, FVMF was not supported as a candidate for managing hepatorenal injury; its reported cytotoxic and anticancer activities require separate evaluation.
Okwulu O. J., R. A. Oguntoye, I. Lawal et al.· International Journal of Bio...· 0 citations
Glyphosate is one of the most widely used herbicides in agriculture. Although it has long been considered relatively harmless to animals, increasing attention has recently been paid to its potential nephrotoxic effect. Therefore, the aim of the present study was to investigate the impact of chronic glyphosate intoxication on renal function in rats and to evaluate the nephroprotective effects of C60 fullerenes as potent antioxidants. Chronic glyphosate exposure (daily dose of 10mg/kg for 16 weeks) was found to impair renal function, as evidenced by increased biochemical indicators. Administration of water-soluble C60 fullerenes (daily dose of 1mg/kg) partially improved the studied biochemical parameters, namely by 16-35 ± 2%, which was further confirmed by histopathological analysis of kidney tissues. These findings suggest that C60 fullerenes may be considered promising nanomaterials for correcting renal dysfunction caused by chronic glyphosate intoxication.
O. Abramchuk, D. Nozdrenko, S. Prylutska et al.· Environmental Toxicology and...· 0 citations
Objective: The objective of the study is to evaluate the nephroprotective potential of Zanthoxylum armatum bark extract Methanolic extract of Zanthoxylum armatum (MZA) against cisplatin (CP)-induced nephrotoxicity in experimental rats.
Methods: Wistar albino rats, weighing between 150 and 200 g, were split into five groups: Normal saline, intraperitoneally CS 16 mg/kg once, and oral methanolic extract of Z. armatum bark at 100, 200, and 400 mg/kg for 42 days. Analyses of serum creatinine, blood urea, blood urea nitrogen, lipid peroxidation (LPO), uric acid, renal enzymatic and non-enzymatic antioxidants, and kidney histopathology were carried out.
Results: Electrolyte imbalance, elevated renal biomarkers, decreased antioxidant enzyme activity, and increased LPO all showed that CS significantly impaired the kidneys and produced oxidative stress (p<0.001). Over 42 days, treatment with the methanolic extract considerably and dose-dependently reduced these changes, restoring renal function indicators, electrolyte balance, and antioxidant status, demonstrating the extract’s strong nephroprotective and antioxidant efficacy.
Conclusion: These results substantiate the ethnomedical usage of Z. armatum bark extract by providing strong evidence that it functions as a powerful scavenger of free radicals and counteracts the harmful effects of CS in both histological and biochemical parameters.
PALLAVI GHILDIYAL, NEERAJ KUMAR, ALOK BHATT et al.· Asian Journal of Pharmaceuti...· 0 citations
