TL;DR
An association between a gut Corynebacterium stationis strain VRD1 333 N7 and early AGE-related and renal biochemical changes in rats is identified, indicating early biochemical and inflammatory alterations, not structural nephropathy.
Gut enrichment of Desulfovibrio and Erysipelotrichaceae may be associated with systemic amino acid metabolic dysfunction, myocardial injury, and heart failure with preserved ejection fraction (HFpEF). These taxa appear to influence host amino acid metabolism through distinct processes, but the functional implications o...
Phlorizin, a major apple-derived dihydrochalcone glycoside, has been reported to contribute to metabolic and inflammatory regulation and has been linked to alterations in the gut microbiota across various disease models, but its relationship with the gut microbiota under normal physiological conditions remains uncl...
Findings identify hepatic CML as an AGE-related feature of steatotic liver disease and demonstrate coordinated mitochondrial, inflammatory, and fibrogenic responses to CML in multicellular HLOs, which support the utility of HLOs for investigating AGE-specific mechanisms in human liver pathology.
Alcoholic liver disease (ALD) is a major global health burden. Cuproptosis, a form of regulated cell death, plays a critical role in multiple liver diseases, yet its role and mechanisms in ALD remain largely unknown. This study explored the preventive and therapeutic roles of mangiferin monosodium salt (MG-Na) against...
Chronic kidney disease (CKD) induces systemic oxidative stress and inflammation, leading to secondary cognitive impairment. The mechanisms by which marine-derived fucoidan exerts neuroprotection remain incompletely understood. Here we show that oral administration of Fucus vesiculosus-derived fucoidan improved object-r...
Abstract Introduction Diabetic kidney disease (DKD) is characterized by impairment of renal glomerular and tubular cells. Low plasma levels of ceramides and lactosylceramides containing very long-chain (VLC) fatty acid were found to be predictive of DKD development. Elongase 1 (Elovl1) is a ubiquitous elongase that elo...
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