Progress in Synthesis and Pharmacology of Telmisartan

Abstract

Telmisartan is a benzimidazole derivative and a well‐known drug to treat hypertension. This is an angiotensin II receptor blocker (ARB) which helps to relax blood vessels. Studies have shown that telmisartan is effective in reducing cardiovascular disease, with a safety and efficacy profile. This review paper provides an overall understanding of telmisartan as an antihypertensive drug. The goal is to highlight the synthetic methodology of telmisartan, from its first synthesis in 1993. This review also discusses its two mechanisms of action: the Renin‐Angiotensin‐Aldosterone System (RAAS) inhibitor and partial agonist activity at the Peroxisome Proliferator‐activated receptor gamma (PPARγ) receptor. Effective repurposing of this drug for various diseases like chronic kidney illness, diabetes, fatty liver, and Alzheimer's has also been discussed.