Small vulnerable newborns and prenatal exposure to organophosphate esters: Insights from the Ma'anshan Birth Cohort.

Prenatal Organophosphate Esters Exposure and Neonatal Birth Outcomes: A Cross-Sectional Study From an Electronic Waste Area.

It is revealed that maternal exposure to OPEs in e-waste recycling areas contributes to increased neonatal birth weight and length, which may elevate the risk of overweight or obesity during later growth.

Associations of Prenatal BTEX Exposure with Preterm Birth: A Nationwide Birth Cohort Study in 337 Chinese Cities.

Long-term exposure to benzene, toluene, ethylbenzene, and xylene (BTEX) has been linked to preterm birth (PTB), yet evidence from China remains limited. This study included 4,321,599 live singleton births from the National Free Preconception Health Examination Project between 2010 and 2015. Prenatal BTEX exposure was estimated using a chemistry-climate model. Multivariate linear regression and logistic regression models were applied to examine associations of BTEX exposure with gestational age and PTB risk, respectively. For the entire pregnancy, each interquartile range (IQR, 11.6 μg/m3) increase in BTEX exposure was associated with a reduction of 0.138 (95% confidence interval [CI]: 0.133-0.142) weeks in gestational age and a 23% (odds ratio [OR]: 1.23, 95% CI: 1.22-1.24) increase in PTB risk. Among individual components, IQR increases in benzene, toluene, and xylenes concentrations were associated with 21% (95% CI: 20-22%), 25% (95% CI: 24-26%), and 20% (95% CI: 19-21%) higher odds of PTB, respectively. The strongest associations were observed for exposures during the third trimester for both BTEX (OR = 1.27, 95% CI: 1.26-1.28) and individual components (benzene: OR = 1.25, 95% CI: 1.24-1.26; toluene: OR = 1.29, 95% CI: 1.28-1.30; and xylenes: OR = 1.25, 95% CI: 1.24-1.26). Subgroup analyses indicated that the associations were more pronounced among male fetuses, mothers who were overweight or obese, engaged in farming, or had lower educational attainment. Prenatal BTEX exposure was significantly associated with an elevated risk of PTB, emphasizing the potential adverse effects of BTEX pollution on maternal and infant health.

Associations of prenatal exposure to organophosphate flame retardants and organophosphorus pesticides with cardiac structure in 4-year-old children: Evidence from the Shanghai Birth Cohort.

Prenatal exposure to OPFRs and OPPs was associated with smaller left ventricular structural measures in early childhood, mainly reflected by lower left ventricular volume and mass, with OPFRs emerging as main contributors and stronger associations among girls.

Prenatal Exposure to Organophosphate Esters and Infantile Neurobehavior: Integrating the Gut Microbiome and Metabolome.

Prenatal TBEP exposure was associated with greater behavioral problems in early childhood, and Alter neonatal gut microbiota and related metabolic pathways may partly underlie this association.

Maternal carbon monoxide exposure and its association with small-for-gestational-age newborns in an Andean city in Colombia

Maternal exposure to particulate matter during pregnancy and offspring liver function.

Air pollution is associated with hepatic dysfunction, but the evidence in the early childhood remains limited. This study aimed to explore the associations between maternal exposure to particulate matter and offspring liver function, as indicated by serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in children aged 1-2 years. Based on the Fujian Birth Cohort Study (FJBCS), a total of 1046 mother-offspring pairs were analyzed in this study. Maternal mean exposures to PM1, PM2.5 and PM10 were calculated for the entire gestational period and each of the three trimesters. Linear regression models were used and restricted cubic spline (RCS) models were further applied to explore the exposure-response relationships. Distributed lag models (DLMs) were conducted to examine the weekly associations throughout pregnancy. Results show that positive associations were found between maternal exposure and offspring enzyme levels in the entire pregnancy as well as the second trimester alone. After adjustment, an interquartile range (IQR) increment in PM1, PM2.5 and PM10 in the second trimester was associated with increases in ALT by 1.42 (0.82-2.03) U/L, 1.41 (0.77-2.05) U/L, 0.91 (0.35-1.46) U/L, and in AST by 1.64 (1.00-2.29) U/L, 1.56 (0.88-2.23) U/L and 0.80 (0.21-1.39) U/L, respectively. DLM analyses further indicated that the associations were the most pronounced during the second trimester. Our findings suggest that maternal exposure to particulate matter is positively associated with increased levels of ALT and AST in offspring, with the second trimester representing a potentially sensitive period.