388. Influence of dysmenorrhea on anxiety and depression in women: aspect from age, menarche, and parity

Abstract

Abstract Background Dysmenorrhea is one of the most prevalent gynecologic disorders among women of reproductive age and exerts substantial impacts on physical health, psychological well-being, and socioeconomic status. Although prior studies have suggested an association between dysmenorrhea and psychological distress, large-scale evidence from Asian populations remains scarce. Aims & Objectives The aim of this study is to clarify the impact of dysmenorrhea on anxiety and depression in women: aspect from Age, Menarche, and Parity. Method This cross-sectional study analyzed data from women under 50 years of age enrolled in the Taiwan Biobank. Dysmenorrhea status was assessed using standardized questionnaires, while psychological distress was measured with the Generalized Anxiety Disorder-2 (GAD-2) and Patient Health Questionnaire-2 (PHQ-2). Multivariable logistic regression models were applied to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the associations between dysmenorrhea and anxiety or depression, which are adjusted for demographic characteristics, lifestyle factors, and gynecologic variables. Stratified analyses were further conducted according to age group, age at menarche, and parity. Results Approximately one-sixth of participants reported dysmenorrhea. After adjusting for potential confounders, women with dysmenorrhea demonstrated significantly higher risks of anxiety (aOR ≈ 1.63) and depression (aOR ≈ 1.77) compared with those without dysmenorrhea. These associations remained consistent across most subgroups including age group, age at menarche, and parity. Detail information will be presented at the congress. Discussion & Conclusions In conclusion, dysmenorrhea is independently associated with elevated risks of anxiety and depression in women before menopause These findings highlight the need for integrated clinical strategies addressing both menstrual pain and mental health, as well as public health initiatives aimed at enhancing menstrual health literacy, promoting healthy lifestyles, and facilitating early psychological screening.