Global Postural Reeducation in Mild Alzheimer's Disease: A Secondary Analysis of an RCT.

Abstract

BackgroundDepression and neuropsychiatric symptoms are common in Alzheimer's disease (AD) and may contribute to functional decline and reduced quality of life.MethodsThis secondary analysis used data from a randomized controlled trial (NCT03732053). Fifty-eight participants were analyzed: 36 received supervised GPR twice weekly for 24 weeks and 22 received usual care. Outcomes included the Geriatric Depression Scale (GDS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Barthel Index, and Performance-Oriented Mobility Assessment (POMA). Repeated-measures ANOVA and baseline-adjusted analyses were performed.ResultsAt 24 weeks, GDS scores were lower with GPR than usual care (4.72 ± 2.36 vs. 8.41 ± 2.15; p < 0.001). Significant group × time effects were observed for NPI, MMSE, Barthel Index, and POMA (all p < 0.001).ConclusionGPR may provide complementary benefits across psychological, cognitive, and functional outcomes in mild AD, although baseline imbalance and differential attrition warrant cautious interpretation.