Emerging Modern Therapeutic Options in Amyotrophic Lateral Sclerosis (ALS)

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by a rapidly progressive clinical course, ultimately leading to complete paralysis and a profound deterioration of physical and cognitive well-being. For decades, riluzole remained the sole approved therapeutic option. The pharmacological landscape has recently experienced significant revolution. While a definitive cure remains elusive, recent advancements have introduced novel, targeted agents into clinical practice, marking a critical milestone in ALS management. This review presents recent findings and emerging trends in ALS pharmacotherapy. Furthermore, it examines the complex pathophysiology of this multidimensional disease, highlighting the intrinsic biological challenges that complicate the development of universally effective, disease-modifying treatments.