Open access
Acinetobacter bereziniae co-producing NDM-1 and OXA-58 causing pneumonia and stomatitis in a Burmese python (Python bivittatus).
G. S. dos Santos
Julia de Menezes Macedo Pausa
Caroline da Costa Abrahão
A. S. de Oliveira
J. Araújo
A. Haisi
L. Sartori
J. Ferreira
M. B. Heinemann
Medicine
Abstract
Carbapenemase-producing Acinetobacter (CPA) are multidrug-resistant pathogens mainly associated with healthcare infections but are increasingly detected in wildlife exposed to human environments. In this study we report and characterize a carbapenem-resistant Acinetobacter bereziniae strain related to fatal pneumonia and stomatitis in a rescued Burmese python (Python bivittatus) in São Paulo, Brazil. Whole genome sequencing revealed plasmid-borne blaNDM-1 and blaOXA-58 genes and phylogenomic analysis clustered the strain with human clinical isolates. These findings highlight the threat of carbapenemase-producing bacteria to wildlife and reinforce the need for a One Health surveillance approach.