Open access
Accelerating rare cancer research: a Zebrafish-First Triage Strategy.
Medicine
TL;DR
A Zebrafish-First Triage Strategy is proposed to screen potential therapeutic targets before mammalian validation and accelerate research and drug development in rare cancers.
Abstract
Rare cancers collectively account for approximately a quarter of diagnosed cancers. However, these tumors remain understudied due to research constraints, including underfunding, scarce samples, and reliance on resource-intensive mouse models. We propose a Zebrafish-First Triage Strategy to screen potential therapeutic targets before mammalian validation and accelerate research and drug development.