The problem of comorbidity of non-psychotic mental and somatic disorders (a literature review)

Abstract

The comorbidity of non‑psychotic mental and somatic disorders is viewed as a stable network of bidirectional relationships between affective, anxiety, personality, and behavioral psychopathology, on the one hand, and cardiometabolic, cardiovascular, pain, gastroenterological, and other somatic conditions, on the other. The review summarizes data from systematic reviews, meta‑analyses, and large cohort studies conducted in recent years. Depressive and anxiety disorders, somatic symptom disorder, personality disorders, the bipolar spectrum, insomnia, and eating disorders are considered. It has been shown that mental and somatic pathology form a single biopsychosocial system in which stress, inflammation, autonomic dysregulation, and sleep and eating disorders are interrelated. Effective management of such patients is possible only with an integrated care model and regular screening for comorbidity.